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- Table of Contents
Facts about Fumarate hydratase, mitochondrial.
Human | |
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Gene Name: | FH |
Uniprot: | P07954 |
Entrez: | 2271 |
Belongs to: |
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class-II fumarase/aspartase family |
EC 4.2.1.2; fumarase; fumarate hydratase; fumarate hydratase, mitochondrial; HLRCC; LRCC; MCL; MCUL1
Mass (kDA):
54.637 kDA
Human | |
---|---|
Location: | 1q43 |
Sequence: | 1; NC_000001.11 (241497603..241519755, complement) |
Expressed in red blood cells; underexpressed in red blood cells (cytoplasm) of patients with hereditary non- spherocytic hemolytic anemia of unknown etiology.
[Isoform Mitochondrial]: Mitochondrion.; [Isoform Cytoplasmic]: Cytoplasm, cytosol. Nucleus. Chromosome. Translocates to the nucleus in response to DNA damage: localizes to DNA double-strand breaks (DSBs) following phosphorylation by PRKDC.
We've been looking at the Boster Bio: Anti-Involucrin (Squamous Cell Terminal Differentiation Marker) Monoclonal Antibody. We've learned about the company's high-affinity primary antibodies and Steven Boster's background. We've also examined Boster Bio's history. Read on to learn more about the company's products and how they can help scientists.
The Boster Bio Anti-Involucrin (Squamal Cell-Tertiary Differentiation Marker) MonoclonAL Antibody reacts with human, canine, monkey and pig cells. It is stable in a freezer for up to six months. The boster bio antibody is prepared in 10mM PBS. The price of the blocking peptide is dependent on the length of the immunogen.
The antibody recognizes involucrin, a 66kDa protein that is found in human keratinocyte culture and stained in various sizes. The epitope of this antibody maps to codons 421-568 of human involucrin. It is expressed in a variety of stratified squamous epithelia, including the cornea, upper spinous layer, and basal layer.
This monoclonal antibody is a recombinant polynucleotide derived from human keratinocytes. It is produced by recombinant techniques and has an IS0140/CAS number. Anti-Involucrin (Squamous Cell Terminal Differentiation Marker) Monoclonal Antibody has been FDA-approved since 2008.
The composition of the immunostimulatory agent further comprises a pharmaceutically acceptable carrier or diluent and an adjuvant to enhance the effectiveness of the immune response. The adjuvant may include saponin-containing compounds or cytolysins, which mediate delivery of the antigen to the target cell cytosol.
The immunostaining method used to test the immunoreactivity of this antibody was a two-step process. The mice were primed and boost immunized with either FPV/MVA, IL-25R/IL-22, or IL-4R antagonist. The immunoreactive ILC2 cells were gated using FITC-conjugated anti-mouse CD3 antibody.
The immune reaction of the anti-Involucrin monoclonal antibody was highly effective in detecting the presence of this protein in ovarian cancer cells. The anti-Involucrin monoclonal antibody was able to inhibit cell adhesion and invasion in vitro. The results were consistent with those of other anti-Involucrin monoclonal antibodies.
The protein PEBP inhibits extracellular signal-regulated protein kinase and reduces cell proliferation. In vitro, involucrin inhibition inhibited human keratinocytes' proliferation by inhibiting PEBP expression. The antibody also inhibits their differentiation. The Boster Bio: Anti-Involucrin (Squamous Cell Terminal Differentiation Marker) Monoclonal Antibody targets both human keratinocytes and Spinous Cells.
The present invention relates to compositions for stimulating an immune response. Anti-Involucrin (Squamous Cell Terminal Differentiation Marker) Monoclonal Antibody is an inhibitor of IL-25. It can be a soluble or defective protein or an oligonucleotide IL25 receptor.
The results of this study showed that the expression of anti-Involucrin is associated with myelination in non-small cell lung cancer cells. The antibody binds to I+-catenin and the Squamous Cell Terminal Differentiation Marker. These findings suggest that anti-Involucrin (Squamous Cell Terminal Differentiation Marker) Monoclonal Antibody is an effective treatment for non-small cell lung cancer.
Moreover, it has been shown that the protein can interact with other proteins by displaying higher affinity. Anti-Involucrin (Squamous Cell Terminal Differentiation Marker) Monoclonal Antibody is a versatile immunodiagnostic tool. It can detect tumors by staining them with the anti-Involucrin (Squamous Cell Terminal Differentiation Marker) Monoclonal Antibody.
Using Boster Bio's high-affinity, single-b cell antibody screening method can provide highly specific and high-affinity antibodies for research purposes. These antibodies compete with ACE2 for binding to the receptor-binding domain, opening the door to new research possibilities. This method uses single B cells to identify potent and high-affinity neutralizing antibodies. Here are three important benefits of Boster Bio's high-affinity primary antibodies:
During ongoing immune responses, the immune system produces a diverse panel of high-affinity primary antibodies, or Abs. To understand the biological limits of repertoire diversification and affinity maturation, the authors conducted an experiment with two adult volunteers who had received three consecutive tetanus toxoid vaccinations. Interestingly, the third vaccination had no significant effect on the proportion of somatic mutations in the Ab repertoire and no significant changes in binding rates. Thus, both repertoires remained comparable in size, genetically diverse, and dynamic.
When the affinity maturation process is impaired, it results in sustained autoimmune disease. Insufficient production of protective IgM antibodies results in the development of an autoimmune disorder. Defective affinity maturation results in an immune response that produces a large amount of non-specific IgG antibodies. Alternatively, the immune system fails to produce any protective IgG antibodies. This leads to an insufficient response to the autoantigen.
A recent study of binding constants in different Ab repertoires showed that they had a log-normal distribution profile, with defined medians and unit-less multiplicative standard deviations. Thus, they can be regarded as biological constants that provide a benchmark for affinity maturation analysis. This is the reason why Boster Bio's high-affinity antibodies are so useful in research. If you are working in a highly specialized field and need high-affinity antibodies, Boster Bio's primary antibodies are an excellent choice.
If you're wondering what Steve Boster was like as a child, you've come to the right place. You can find public records and information about Steve Boster, including his current address, past addresses, mobile phone numbers, and email addresses. You can also search for people named Steven Boster and their known relatives. You can filter the results by age and state to find specific information about this man. And there are several ways to find out more about Steve Boster.
Steve Boster's history starts with his birth, June 26, 1920, in Joliet, IL. His parents were James Boster and Evelyn Meier. He worked as a retail sales manager for many years. He was also a veteran of the U.S. Army and a member of Concordia Hall in Staunton, VA. Boster is survived by his daughters Natosha Peck and Crystal Boster, six grandchildren, and 4 brothers. He is also survived by his sisters, Kimberly Blanton, Tammy Boster, and Jonathan, and by numerous nieces and nephews.
PMID: 3828494 by Kinsella B.T., et al. Nucleotide sequence of a cDNA coding for mitochondrial fumarase from human liver.
PMID: 27037871 by Dik E., et al. Human fumarate hydratase is dual localized by an alternative transcription initiation mechanism.