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FGFR2 Antibodies
AND FGFR2 ELISA kits, FGFR2 Proteins
Many biological assays use antibodies to detect FGFR2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FGFR2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FGFR2 antibodies...
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FGFR2 Infographic by Boster Bio
All FGFR2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1213
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1213
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
Flow Cytometry, IF, IHC, WB
$523
Cat # M00231-2
100 µl
Cat # M00231-2
100 µl
Human, Mouse, Rat
IF, IHC, WB
$523
Cat # M00231-1
100 µl
Cat # M00231-1
100 µl
FGFR2 Overview
Facts about Fibroblast growth factor receptor 2.
Fibroblast growth factor receptor 2 (FGFR2)
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a vital role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development.
Plays an important role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts.
Gene Information
| Human | |
|---|---|
| Gene Name: | FGFR2 |
| Uniprot: | P21802 |
| Entrez: | 2263 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
BBDS; BEK; BFR-1; CD332 antigen; CD332; CEK3; CFD1; craniofacial dysostosis 1; EC 2.7.10; EC 2.7.10.1; ECT1; FGF R2; FGFR2; fibroblast growth factor receptor 2; FLJ98662; Jackson-Weiss syndrome; JWS; Keratinocyte growth factor receptorreceptor like 14; KGFR; KSAM; K-sam; soluble FGFR4 variant 4; TK14; TK25
Molecular Weight
Mass (kDA):
92.025 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q26.13 |
| Sequence: | 10; NC_000010.11 (121478330..121598458, complement) |
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Golgi apparatus. Cytoplasmic vesicle. Detected on osteoblast plasma membrane lipid rafts. After ligand binding, the activated receptor is rapidly internalized and degraded.; [Isoform 1]: Cell membrane; Single-pass type I membrane protein. After ligand binding, the activated receptor is rapidly internalized and degraded.; [Isoform 3]: Cell membrane; Single-pass type I membrane protein. After ligand binding, the activated receptor is rapidly internalized and degraded.; [Isoform 8]: Secreted.; [Isoform 13]: Secreted.
Diseases
- Malignant Neoplasms
- Craniosynostosis
- Neoplasms
- Acrocephalosyndactylia
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Craniofacial Dysostosis
- Apert Syndrome
- Carcinoma
- Pfeiffer Syndrome
- Tumor Angiogenesis
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Stomach
Interacting Proteins
- FGF1
- FGF10
- FGF2
- FGF7
- GRB2
- PLCG1
Pathways
- Cell Proliferation
- Angiogenesis
- Localization
- Cell Growth
- Pathogenesis
- Regeneration
- Cell Differentiation
- Ossification
- Cell Cycle
- Osteoblast Differentiation
- Cell Migration
- Wound Healing
- Cell Death
PTMs
- Phosphorylation
- Methylation
- Cleavage
- Ubiquitination
- Glycosylation
- Acetylation
- Deacetylation
Research Areas
- Angiogenesis
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FGFR2
bosterbio.com/bosterbio-gene-info-cards/FGFR2
References
PMID: 1697263 by Dionne C.A., et al. Cloning and expression of two distinct high-affinity receptors cross- reacting with acidic and basic fibroblast growth factors.
PMID: 2172978 by Houssaint E., et al. Related fibroblast growth factor receptor genes exist in the human genome.