FGFBP1 Antibodies

Fibroblast growth factor-binding protein 1 (FGFBP1)

Acts as a carrier protein that release fibroblast- binding factors (FGFs) in the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Improves FGF2 signaling during tissue repair, angiogenesis and in tumor development.

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Gene Information

Human
Gene Name:	FGFBP1
Uniprot:	Q14512
Entrez:	9982

Family

Belongs to:
fibroblast growth factor-binding protein family

Alternative Names

17 kDa heparin-binding growth factor-binding protein; FGFBP; FGF-BP; FGFBP1; FGF-BP1; FGFBP-1; FGFBPFGF-binding protein 1; fibroblast growth factor binding protein 1; fibroblast growth factor-binding protein 1; HBp17; HBP1717 kDa HBGF-binding protein; heparin-binding growth factor binding protein

Molecular Weight

Mass (kDA):
26.264 kDA

Genomic Context

Human
Location:	4p15.32
Sequence:	4; NC_000004.12 (15935577..15938740, complement)

Tissue Specificity

Expressed in the suprabasal region of the epidermis, in hair follicles, the basement membrane at the dermo- epidermal junction (occasionally extending into the basement membrane of dermal blood vessels), wounded skin and several invasive squamous cell carcinomas (at protein level). Expressed in normal and wounded skin and various squamous cell carcinomas.

Subcellular Localizations

Secreted, extracellular space. Cell membrane; Peripheral membrane protein. Extracellular and plasma membrane-associated. Colocalizes with HSPG2 in the pericellular environment of squamous cell carcinomas.

Diseases

• Neoplasms
• Tumor Angiogenesis
• Malignant Neoplasms
• Carcinoma
• Malignant Squamous Cell Neoplasm
• Pathologic Neovascularization
• Cell Transformation, Neoplastic
• Malignant Paraganglionic Neoplasm
• Skin Neoplasms
• Neoplasm Metastasis
• Malignant Neoplasm Of Breast
• Mammary Neoplasms

• Carcinogenesis
• Cell Invasion
• Colonic Neoplasms
• Dysplasia
• Adenocarcinoma
• Liver Carcinoma

Interacting Proteins

• FGF2

Pathways

• Angiogenesis
• Wound Healing
• Cell Proliferation
• Pathogenesis
• Secretion
• Cell Migration
• Rna Interference
• Chemotaxis
• Localization
• Regeneration
• Cell Growth
• Transport
• Protein Phosphorylation

• Proteolysis
• Regulation Of Gene Expression
• Endothelial Cell Proliferation
• Cell Cycle Arrest
• Embryo Development
• Cell Maturation
• Sensitization

PTMs

• Phosphorylation
• Cleavage

• Methylation
• Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FGFBP1

Best Uses Of The FGFBP1 Marker From Boster Bio

The FGFBP1 mark is a biologically relevant protein. It enhances FGF2 signaling during tissue repair, angiogenesis and tumor development. It regulates metabolism. FGFBP can also be detected using biological assays

Detects dysfunctional immune cells

In this invention, a FGFBP1 marker that is specific for immune cells is provided. The FGFBP1 marker is useful in identifying a dysfunctional immune cells. This is a protein which is expressed on immune cell. This protein comes from fibroblasts. This protein is responsible to the production of FGF (fibroblast growth factor) and is highly expressed by immune cells.

The biomarker is based on the co-expression and expression of many transcriptional regulators. It identifies T cells that are in a disordered or abnormal state. These receptors co-expression suggests a common trigger that causes dysfunctional T cells to respond. The discovery of common regulatory mechanisms may lead to better therapies for immune-cell disorders. These molecules could be used to monitor patients with autoimmune diseases' effectiveness.

Boster Bio FGFBP1 ligand is an antigen specific ligand for T cells that can detect functionally exhausted cells. These unresponsive immune cells are characterized by a loss of cytotoxic activity, cytokine production, and proliferation. They also have a reduced ability of phagocytose, and elicit a reaction from other immune cell types.

Boster Bio also sells a functional FGFBP1 gene that can be used to detect immunologically T cells. These markers can be used for diagnostic and research purposes. Boster Bio FGFBP1 markers are available for use in many clinical settings, even on patients with cancer. FGFBP1's function and expression are affected by many factors. FGFBP1 acts as an immunologic indicator and is associated with increased activity in cMAF, IL27, PRDM1 and PRDM2.

Detects fibroblast cell growth factor

The FGFBP1 marker from Boster Bio is a highly sensitive and specific fibroblast marker that can detect a range of levels of this growth factor. FGFBP1 proteins are a major factor in fibroblast development. It can also play a wide range of pathological and physiological roles. It is an important therapeutic target for gene therapy, as it is associated with a range of a number of diseases, including fibroblasts, a type of blood-forming cell.

This FGFBP1 mark is based on the gene that encodes this protein. It is a member of the fibroblast growth factor family and is involved in tissue repair and tumor development. It can also serve as an immunohistochemical analyzer. It is therefore useful in detecting FGF levels at tumors. For example, Wu et al. Wu et al. have shown that FGFBP1 overexpression increases tumorigenicity of SW-13 cells and induces angiogenesis using an assay using the chorioallantoic cell membrane.

RNAi-mediated FGFBP knockdown inhibits tumor cells through targeting heparin bind protein. This allows for a more targeted targeting FGF-BP. In one study, mice with established tumor xenografts were treated with PEI-complexed FGF-BP-specific siRNAs, while the control group received non-specific siRNAs. The tumor growth rate of mice with tumors was 40% lower.

FGFBP expression does not increase apoptosis rates in LS174T cell lines. FGFBP expression did not increase caspase-3/7 activities. This effect is independent of cultivation conditions, serum concentrations, or FGF-BP-BP levels. FGFBP-BP knockdown can inhibit apoptosis even in cells that aren't hyperexpressed.

Anchorage-dependent proliferation was significantly reduced by knockdown of FGFBP. This was more than twice the amount of wt cells. Negative control shRNA-transfected cells only showed a slight decrease in colony formation. The decrease in colony formation was not further increased. The FGF-BP knockdown also reduced colony formation. Overall, the FGF-BP knockdown reduced anchorage-independent proliferation.

In vitro studies with HT29 cell culture showed that the combination IGF1 plus basic FGFBP1 facilitated ligament development. The sequential approach was also successful at preventing somatic cell growth. The combined approach allows for a better understanding and application of molecular mechanisms that regulate fibroblast cell growth. Further studies on FGF-BP, IGF-1 and other growth factors will help us understand the role they play in fibroblast formation.

Regulates metabolism

A novel nuclear protein, VprBP, has the ability to bind to HIV viral protein R and the Cullin 4-DDB1 ubiquitin ligase complex. Cell 140:477-490 reported this interaction. HIV replication is a process that involves both wild-type and mutant forms of VprBP. To determine their functional differences in HIV replication, further structural- and biological analyses of Bub1 as well as Bub1 are necessary.