FGF22 Antibodies

Fibroblast growth factor 22 (FGF22)

Plays a role in the fasting reaction, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro).

May be involved in hair development. .

Gene Information

Human
Gene Name:	FGF22
Uniprot:	Q9HCT0
Entrez:	27006

Family

Belongs to:
heparin-binding growth factors family

Alternative Names

FGF22; FGF-22; fibroblast growth factor 22

Molecular Weight

Mass (kDA):
19.663 kDA

Genomic Context

Human
Location:	19p13.3
Sequence:	19; NC_000019.10 (639879..644373)

Subcellular Localizations

Secreted.

Diseases

• Carcinogenesis
• Neoplasms
• Skin Wound
• Papilloma
• Malnutrition
• Metaplasia
• Retinal Degeneration
• Malignant Neoplasm Of Breast
• Endometrial Polyp
• Malignant Neoplasm Of Lung
• Dysplasia

• Malignant Neoplasms
• Nervousness
• Scoliosis, Unspecified
• Malignant Neoplasm Of Ovary
• Kindling, Neurologic

Pathways

• Cell Proliferation
• Cell Development
• Proteolysis
• Synaptic Transmission
• Skin Development
• Chondrocyte Differentiation
• Senescence
• Synaptic Vesicle Clustering
• Tissue Remodeling
• Regulation Of Cell Proliferation

• Cell Differentiation
• Wound Healing
• Pathogenesis
• Tissue Homeostasis

PTMs

• Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FGF22

Boster Bio - Best Uses Of The FGF22 Marker

If you've been wondering whether Boster Bio's Anti-Fibroblast Growth Factor 22 FGF22 Marker is right for your research, read on to learn more about its benefits and applications. There are many options for how to use this biomarker. Let's take a look at a few. First, we'll discuss the various species and applications this biomarker is capable of being used for.

Boster Bio's Anti-Fibroblast Growth Factor 22 FGF22 marker

Boster bio's Anti-Fibroblast Growth Factor 22 - Marker (FGF22), a monoclonal antibodies to the human FGF22 gene, is available as a monoclonal marker. It is available for WB applications. The antibody has been tested to determine if it reacts with human, mouse and rat proteins. It also reacts to a wide variety of fibroblast growth factors.

It is also effective against apoptosis induced ER stress. Moreover, it inhibits the expression of caspase-12, GRP78, and CHOP proteins, which are implicated in apoptosis. The FGF22 marker inhibits the apoptosis response when compared to the respective control group. The inhibitory effect is stronger if FGF22 is present in higher concentrations.

FGF22 is a marker that detects the effects FGF22 has on axons. When axons break, the spinal cord is damaged. It is therefore very difficult to regenerate them. FGF22 enhances axon regeneration by increasing their number. Researchers found that mice receiving FGF22 at a dose of 10 mg/ml had an increase in axon regeneration.

In addition, the FGF-22 marker inhibits the proliferation of tumor cells by blocking the expression of tumor-associated fibroblast growth factor (FGF)-2. It promotes neovascularization, which in turn inhibits the proliferation and proliferation of tumor cells. FGF-22 markers are an important tool for cancer research. But it can be difficult to identify a target using a nonspecific FGF22 antibody.

Applications

The FGF22 gene performs many functions. It belongs to the FGF fibroblast growth factor family. This is important for many biological processes. FGF22 homolog in mice is found in the inner roots sheath of hair hair follicles. This suggests a possible role for the gene in hair development. Here are some examples that the FGF22 mark can be used. (See the table to find out more.

FGF22 promotes synaptic accumulation at excitatory neuro terminals in vivo. FGF22 null mice do not produce synaptic vessels at excitatory nerve termins in the CA3 area of the hippocampus. This protein is a target presynaptic planner that rescues FGF22 knockout animals.

The CA3-derived FGF22 plays an important role in the formation of local neurons and affective behavior. These data demonstrate the crucial role of FGF signaling for brain development and function. FGF22 is also involved with dentate neurogenesis. Applications of FGF22 can have broad implications for the development and functioning of the human brain. However, at this time, there is no cure.

Besides its many applications, FGF22 also has a number of pharmacological, chemical, and cellular biology. FGF22 regulates excitatory stimulation in the CA3 brain area. It is also expressed at a subset DGCs of the hippocampal. In a recent study, FGF22f/f mice were crossed with Grik4-Cre mice, which express Cre in most of their CA3 pyramidal neurons.

FGF22 has been shown to increase insulin -like growth factor 2, when applied in the human brain. Doublecortin, a marker for mature neurons, was also detected in axes from CA3 pyramidal neural neurons. FGF22 null mice showed significantly lower DCX positivity at the dentate-granule cell layer. This study suggests that FGF22 contributes throughout life to dentate neurogenesis.

Benefits

The brain health is positively correlated with the level of FGF22 expression in the CNS. The FGF22 marker is found in a variety of tissues including the heart and gastrointestinal tract. It could also be used to target HD therapies. FGF9 remains to be studied in detail. Although there is still much to learn about the potential benefits of FGF9, this marker can be used to help early detection of the disease.

A tumor that is affected by FGF22 will have a lower chance of dying. FGF22 knockout mice have a longer time of floating. FGF22 knockout mice are more inclined to consume sucrose than their counterparts. It is not significantly different than the FGF22 deficient mice in behavioral assays like motor tests, anxiety, or social cognitive testing.