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FGF1 Antibodies
AND FGF1 ELISA kits, FGF1 Proteins
Many biological assays use antibodies to detect FGF1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FGF1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FGF1 antibodies...
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FGF1 Infographic by Boster Bio
All FGF1 Products
Product
Figures
Specificity
Applications
Price
Anti-FGF1 Antibody Picoband®
1 Citations
Human, Mouse, Rat
ELISA, IHC, WB
$370
Cat # PB9944
100 μg/vial
Cat # PB9944
100 μg/vial
Human FGF1/Fgf Acidic ELISA Kit PicoKine®
2 Citations 11 Q&As
Human
ELISA
$499
Cat # EK0339
96 wells/kit, with removable strips.
Cat # EK0339
96 wells/kit, with removable strips.
Mouse
ELISA
$499
Cat # EK1172
96 wells/kit, with removable strips.
Cat # EK1172
96 wells/kit, with removable strips.
Rat FGF1/Fgf Acidic ELISA Kit PicoKine®
3 Citations 6 Q&As
Rat
ELISA
$499
Cat # EK1173
96 wells/kit, with removable strips.
Cat # EK1173
96 wells/kit, with removable strips.
Anti-Fibroblast growth factor 1 FGF1 Antibody Picoband®
2 Citations 3 Q&As
Human
ELISA, IHC, WB
$370
Cat # RP1005
100 μg/vial
Cat # RP1005
100 μg/vial
Equine
ELISA
$499
Cat # EK0339-EQ
96 wells/kit, with removable strips.
Cat # EK0339-EQ
96 wells/kit, with removable strips.
Monkey
ELISA
$499
Cat # EK0339-PR
96 wells/kit, with removable strips.
Cat # EK0339-PR
96 wells/kit, with removable strips.
Rat
$250
Cat # PROTP61149
10ug, 50ug, 1mg
Cat # PROTP61149
10ug, 50ug, 1mg
Human, Mouse, Rat
IF, WB
$523
Cat # M00206
100 µl
Cat # M00206
100 µl
Human
Cell Culture
$77
Cat # PROTP05230-4
5ug,20ug,100ug
Cat # PROTP05230-4
5ug,20ug,100ug
FGF1 Overview
Facts about Fibroblast growth factor 1.
Fibroblast growth factor 1 (FGF1)
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.
Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades.
Gene Information
| Human | |
|---|---|
| Gene Name: | FGF1 |
| Uniprot: | P05230 |
| Entrez: | 2246 |
Family
| Belongs to: |
|---|
| heparin-binding growth factors family |
Alternative Names
AFGF; alpha; alpha-ECGF; beta-ECGF; ECGF; ECGFB; ECGF-betaAcidic fibroblast growth factor; endothelial cell growth factor, beta; FGF acidic; FGF-1; FGFABeta-endothelial cell growth factor; FGF-alpha; fibroblast growth factor 1 (acidic); GLIO703; HBGF1; HBGF-1; heparin-binding growth factor 1
Molecular Weight
Mass (kDA):
17.46 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q31.3 |
| Sequence: | 5; NC_000005.10 (142592178..142698070, complement) |
Tissue Specificity
Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle.
Subcellular Localizations
Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59.
Diseases
- Neoplasms
- Malignant Neoplasms
- Tumor Angiogenesis
- Pathologic Neovascularization
- Carcinoma
- Mammary Neoplasms
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Breast
- Cell Transformation, Neoplastic
- Nervousness
- Inflammation
- Tumor Progression
Interacting Proteins
- FGFR1
- FGFR2
- FGFR3
Pathways
- Cell Proliferation
- Angiogenesis
- Secretion
- Cell Growth
- Localization
- Cell Cycle
- Cell Differentiation
- Cell Death
- Regeneration
- Neurogenesis
- Wound Healing
- Sulfation
- Translation
PTMs
- Phosphorylation
- Cleavage
- Glycosylation
- Sulphation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FGF1
bosterbio.com/bosterbio-gene-info-cards/FGF1
References
PMID: 3523756 by Jaye M., et al. Human endothelial cell growth factor: cloning, nucleotide sequence, and chromosome localization.
PMID: 2590193 by Mergia A., et al. Structural analysis of the gene for human acidic fibroblast growth factor.
8 Publications of Boster FGF1 Antibodies & ELISA Kits
- PubMed ID: 10.3389/fnagi.2020.590530, Long-Term Running Exercise Delays Age-Related Changes in White Matter in Rats
- PubMed ID: 10.1016/j.ijcard.2008.12.193, Autologous transplantation of EPCs encoding FGF1 gene promotes neovascularizatio...
- PubMed ID: 10.1016/j.carbpol.2017.05.035, Study of a new biodegradable hernia patch to repair abdominal wall defect in rat...
- PubMed ID: 10.1016/j.actbio.2019.10.011, Biomimetic hydrogel for rapid and scar-free healing of skin wounds inspired by t...
- PubMed ID: 10.1007/s00299-021-02809-y, CRISPR/Cas9-mediated knockout of the DCL2 and DCL4 genes in Nicotiana benthamian...
- PubMed ID: -, Bing-Jie Hu,Jia-Zhen Zhu,Sequence and time course of depletion of cardiac cellul...
- PubMed ID: 25667662, Zhang L, Wang H, Wang T, Jiang N, Yu P, Chong Y, Fu F. Exp Ther Med. 2015 Mar;9(...
- PubMed ID: 21461910, Zhou Y, Ren L, Zhu J, Yan S, Wang H, Song N, Li L, Ouyang H, Pang D. Mol Cell Bi...
*More publications can be found for each product on its corresponding product page