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Fermitin family homolog 2 Antibodies
AND FERMT2 ELISA kits, Fermitin family homolog 2 Proteins
Many biological assays use antibodies to detect Fermitin family homolog 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Fermitin family homolog 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Fermitin family homolog 2 antibodies...
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FERMT2 Infographic by Boster Bio
All FERMT2 Products
Product
Figures
Specificity
Applications
Price
Dog, Human, Monkey, Mouse, Rat
IP, IF, IHC, WB
$523
Cat # M03653
100 µl
Cat # M03653
100 µl
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A03653-1
100 μg/vial
Cat # A03653-1
100 μg/vial
FERMT2 Overview
Facts about Fermitin family homolog 2.
Fermitin family homolog 2 (FERMT2)
Scaffolding protein which enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Enhances integrin-mediated cell adhesion on the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes.
Required for the assembly of focal adhesions. Participates in the link between extracellular matrix adhesion sites and the actin cytoskeleton and in the orchestration of actin assembly and cell shape modulation.
Gene Information
| Human | |
|---|---|
| Gene Name: | FERMT2 |
| Uniprot: | Q96AC1 |
| Entrez: | 10979 |
Family
| Belongs to: |
|---|
| kindlin family |
Alternative Names
fermitin family homolog 2 (Drosophila); fermitin family homolog 2; fermitin family member 2; FERMT2; KIND2; KIND2DKFZp686G11125; kindlin 2; Kindlin-2; MIG2; mig-2; MIG2FLJ34213; mitogen inducible gene 2 protein; Mitogen-inducible gene 2 protein; PH domain-containing family C member 1; pleckstrin homology domain containing, family C (with FERM domain) member 1; pleckstrin homology domain containing, family C member 1; Pleckstrin homology domain-containing family C member 1; PLEKHC1; PLEKHC1FLJ44462; UNC112; UNC112B
Molecular Weight
Mass (kDA):
77.861 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q22.1 |
| Sequence: | 14; NC_000014.9 (52857271..52951097, complement) |
Tissue Specificity
Ubiquitous. Found in numerous tumor tissues.
Subcellular Localizations
Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Cell junction, focal adhesion. Membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, myofibril, sarcomere, I band. Cell surface. Colocalizes with actin stress fibers at cell-ECM focal adhesion sites. Colocalizes with ITGB3 at lamellipodia at the leading edge of spreading cells. Binds to membranes that contain phosphatidylinositides.
Diseases
- Malignant Tumor Of Colon
- Malignant Neoplasms
- Neoplasms
- Cell Invasion
- Neoplasm Metastasis
- Colonic Neoplasms
- Genomic Instability
- Malignant Paraganglionic Neoplasm
- Tissue Adhesions
Interacting Proteins
- CTNNB1
- TCF4
Pathways
- Methylation
- Reverse Transcription
- Integrin Activation
- Dna Methylation
- Cell Growth
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FERMT2
bosterbio.com/bosterbio-gene-info-cards/FERMT2
References
PMID: 8175911 by Wick M., et al. Identification of serum-inducible genes: different patterns of gene regulation during G0->S and G1->S progression.
PMID: 12697302 by Weinstein E.J., et al. URP1: a member of a novel family of PH and FERM domain-containing membrane-associated proteins is significantly over-expressed in lung and colon carcinomas.