Fermitin family homolog 1 Antibodies

AND FERMT1 ELISA kits, Fermitin family homolog 1 Proteins

Many biological assays use antibodies to detect Fermitin family homolog 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Fermitin family homolog 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Fermitin family homolog 1 antibodies...

We validate the specificity of these antibodies to Fermitin family homolog 1 by testing them on tissues known to express FERMT1 positively and negatively. Browse below to find the FERMT1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FERMT1 Infographic by Boster Bio

All FERMT1 Products

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Kindlin (FERMT1) (NM_017671) Human Recombinant Protein

$1249
Cat # PROTQ9BQL6
20 µg

Kindlin (FERMT1) (NM_017671) Human Over-expression Lysate

Human

$960
Cat # LS055612
100 µg

FERMT1 Overview

Facts about Fermitin family homolog 1.

FERMT1 3D structure. Source: alphafold

Fermitin family homolog 1 (FERMT1)

Involved in cell adhesion. Contributes to integrin activation.

When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation.

Gene Information

Human
Gene Name:	FERMT1
Uniprot:	Q9BQL6
Entrez:	55612

Family

Belongs to:

kindlin family

Alternative Names

C20orf42fermitin family homolog 1; chromosome 20 open reading frame 42; fermitin family homolog 1 (Drosophila); fermitin family member 1; FLJ20116; KIND1DTGCU2; kindlerin; kindlin 1; Kindlin syndrome protein; Kindlin-1; UNC112 related protein 1; UNC112A; Unc-112-related protein 1; URP1FLJ23423

Molecular Weight

Mass (kDA):
77.437 kDA

Genomic Context


Human

Location:	20p12.3
Sequence:	20; NC_000020.11 (6074845..6123609, complement)

Tissue Specificity

Expressed in brain, skeletal muscle, kidney, colon, adrenal gland, prostate, and placenta. Weakly or not expressed in heart, thymus, spleen, liver, small intestine, bone marrow, lung and peripheral blood leukocytes. Overexpressed in some colon and lung tumors. In skin, it is localized within the epidermis and particularly in basal keratocytes. Not detected in epidermal melanocytes and dermal fibroblasts.

Subcellular Localizations

Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Constituent of focal adhesions. Localized at the basal aspect of skin keratinocytes, close to the cell membrane. Colocalizes with filamentous actin. Upon TGFB1 treatment, it localizes to membrane ruffles.

Diseases

Poikiloderma Of Kindler
Bulla
Tissue Adhesions
Photosensitivity Disorders
Skin Diseases, Genetic
Epidermolysis Bullosa
Periodontal Diseases
Malignant Neoplasms
Atrophy
Neoplasms
Atrophic Condition Of Skin
Rothmund-thomson Syndrome

Dermatologic Disorders
Carcinoma
Cell Invasion
Malignant Neoplasm Of Skin
Inflammation
Colitis

Pathways

Integrin Activation
Cell Adhesion
Pigmentation
Localization
Cell Proliferation
Cell Growth
Pathogenesis
Cell Migration
Cell-matrix Adhesion
Inflammatory Response
Cell Motility
Actin Cytoskeleton Organization
Cytokine Secretion

Keratinocyte Migration
Cytoskeleton Organization
Reverse Transcription
Translation
Keratinocyte Proliferation
Wound Healing
Mitotic Recombination

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FERMT1

References

PMID: 12697302 by Weinstein E.J., et al. URP1: a member of a novel family of PH and FERM domain-containing membrane-associated proteins is significantly over-expressed in lung and colon carcinomas.

PMID: 12789646 by Siegel D.H., et al. Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome.