FCGRT Antibodies

AND FCGRT ELISA kits, FCGRT Proteins

Many biological assays use antibodies to detect FCGRT, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FCGRT in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FCGRT antibodies...

We validate the specificity of these antibodies to FCGRT by testing them on tissues known to express FCGRT positively and negatively. Browse below to find the FCGRT antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FCGRT Infographic by Boster Bio

All FCGRT Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-FCGRT Antibody Picoband®

Human

IHC, WB

$370
Cat # PB9866
100 μg/vial

Anti-FCGRT Antibody Picoband®

7 Q&As

Mouse

ELISA, IHC, WB

$370
Cat # PB9867
100 μg/vial

Mouse FCRN/FCGRT ELISA Kit PicoKine®

8 Q&As

Mouse

ELISA

$750
Cat # EK1454
96 wells/kit, with removable strips.

FCGRT (NM_001136019) Human Recombinant Protein

$1062
Cat # PROTP55899
20 µg

Mouse Fcgrt Recombinant Protein

SDS-PAGE

$265
Cat # PROTQ61559
Starting from 10ug

FCGRT Overview

Facts about IgG receptor FcRn large subunit p51.

FCGRT 3D structure. Source: alphafold

IgG receptor FcRn large subunit p51 (FCGRT)

Binds to the Fc region of monomeric immunoglobulins gamma (PubMed:7964511, PubMed:10933786). Mediates the selective uptake of IgG from milk and assists newborn animals to acquire passive immunity.

IgG in the milk is bound at the apical surface of the intestinal epithelium. The consequent FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is discharged from FcRn into blood or tissue fluids (By similarity).

Gene Information

Human
Gene Name:	FCGRT
Uniprot:	P55899
Entrez:	2217

Family

Belongs to:

immunoglobulin superfamily

Alternative Names

alpha-chain; Fc fragment of IgG, receptor, transporter, alpha; FCGRT; FcRn alpha chain; FCRN; FCRNimmunoglobulin receptor, intestinal, heavy chain; IgG Fc fragment receptor transporter alpha chain; IgG receptor FcRn large subunit p51; major histocompatibility complex class I-like Fc receptor; Neonatal Fc receptor; neonatal Fc-receptor for Ig

Molecular Weight

Mass (kDA):
39.743 kDA

Genomic Context


Human

Location:	19q13.33
Sequence:	19; NC_000019.10 (49512661..49526428)

Tissue Specificity

Expressed in full-term placenta, heart, lung, liver, muscle, kidney, pancreas, and both fetal and adult small intestine.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein. Endosome membrane.

Diseases

Variable Number Tandem Repeat
Autoimmune Reaction
Dysequilibrium Syndrome
Common Variable Immunodeficiency
Tetanus
Neurofibromatosis 1
Lupus Nephritis
Autoimmune Diseases
Glaucoma
Blind Vision

Intestinal Diseases
Immunologic Deficiency Syndromes
Disorder Of Eye
Nephritis
Lupus Erythematosus, Systemic

Pathways

Transport
Cytokine Production
Dna Amplification
Cell Death
Localization

PTMs

Disulfide bond

Glycoprotein

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FCGRT

References

PMID: 7964511 by Story C.M., et al. A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus.

PMID: 10998088 by Mikulska J.E., et al. Cloning and analysis of the gene encoding the human neonatal Fc receptor.