F-box only protein 22 Antibodies

AND FBXO22 ELISA kits, F-box only protein 22 Proteins

Many biological assays use antibodies to detect F-box only protein 22, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with F-box only protein 22 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop F-box only protein 22 antibodies...

We validate the specificity of these antibodies to F-box only protein 22 by testing them on tissues known to express FBXO22 positively and negatively. Browse below to find the FBXO22 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FBXO22 Infographic by Boster Bio

All FBXO22 Products

Product

Figures

Specificity

Applications

Price

Anti-F-box only protein 22 FBXO22 Antibody

Human

$405
Cat # A09447
100ul

Anti-FBXO22 Mouse Monoclonal Antibody [Clone ID: OTI1H1]

Human, Mouse, Rat

$560
Cat # M09447
100 µl

FBXO22 (NM_147188) Human Over-expression Lysate

Human

$628
Cat # LS026263
100 µg

FBXO22 Overview

Facts about F-box only protein 22.

FBXO22 3D structure. Source: alphafold

F-box only protein 22 (FBXO22)

Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.

Gene Information

Human
Gene Name:	FBXO22
Uniprot:	Q8NEZ5
Entrez:	26263

Family

Belongs to:

No superfamily

Alternative Names

F-box only protein 22; F-box protein 22; F-box protein FBX22p44; FBX22FLJ13986; FIST domain containing 1; FISTC1; MGC31799

Molecular Weight

Mass (kDA):
44.508 kDA

Genomic Context


Human

Location:	15q24.2
Sequence:	15; NC_000015.10 (75903859..75942511)

Tissue Specificity

Predominantly expressed in liver, also enriched in cardiac muscle.

Subcellular Localizations

Cytoplasm, myofibril, sarcomere, Z line.

Diseases

Infective Disorder
Kidney Calculi
Malignant Neoplasms
Chronic Infectious Disease
Neoplasms
Kidney Failure, Chronic
Kidney Diseases
Chronic Kidney Disease

Salmonella Infections
Tissue Damage

Interacting Proteins

SKP1

Pathways

Methylation
Cell Cycle
Histone Acetylation
Dna Methylation
Regulation Of Gene Expression
Intracellular Signal Transduction
Rna Interference
Glomerular Filtration

Secretion
Demethylation

PTMs

Methylation

Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FBXO22

References

PMID: 10531035 by Cenciarelli C., et al. Identification of a family of human F-box proteins.

PMID: 22972877 by Spaich S., et al. F-box and leucine-rich repeat protein 22 is a cardiac-enriched F-box protein that regulates sarcomeric protein turnover and is essential for maintenance of contractile function in vivo.