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- Table of Contents
Facts about F-box/LRR-repeat protein 3.
The SCF(FBXL3) complex chiefly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2 (PubMed:17463251, PubMed:23452855, PubMed:27565346). Action of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complicated (PubMed:23452855).
Human | |
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Gene Name: | FBXL3 |
Uniprot: | Q9UKT7 |
Entrez: | 26224 |
Belongs to: |
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No superfamily |
FBL3AF-box and leucine-rich repeat protein 3AF-box protein Fbl3a; FBL3F-box/LRR-repeat protein 3; F-box and leucine-rich repeat protein 3; F-box/LRR-repeat protein 3A; FBXL3A
Mass (kDA):
48.707 kDA
Human | |
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Location: | 13q22.3 |
Sequence: | 13; NC_000013.11 (76992597..77027164, complement) |
Widely expressed.
Nucleus. Cytoplasm. Predominantly nuclear.
PMID: 10531035 by Cenciarelli C., et al. Identification of a family of human F-box proteins.
PMID: 17463251 by Busino L., et al. SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins.