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- Table of Contents
Facts about Fibulin-5.
Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which might play a role in vascular development and remodeling (PubMed:10428823).
Human | |
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Gene Name: | FBLN5 |
Uniprot: | Q9UBX5 |
Entrez: | 10516 |
Belongs to: |
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fibulin family |
ARMD3fibulin-5; DANCE; DANCEFIBL-5; Developmental arteries and neural crest EGF-like protein; EVEC; FBLN5; Fibulin 5; UP50; UP50FLJ90059; Urine p50 protein
Mass (kDA):
50.18 kDA
Human | |
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Location: | 14q32.12 |
Sequence: | 14; NC_000014.9 (91869411..91947702, complement) |
Expressed in skin fibroblasts (at protein level)(PubMed:17035250). Expressed predominantly in heart, ovary, and colon but also in kidney, pancreas, testis, lung and placenta. Not detectable in brain, liver, thymus, prostate, or peripheral blood leukocytes (PubMed:10428823).
Secreted. Secreted, extracellular space, extracellular matrix. co-localizes with ELN in elastic fibers.
PMID: 10428823 by Nakamura T., et al. DANCE, a novel secreted RGD protein expressed in developing, atherosclerotic, and balloon-injured arteries.
PMID: 15790312 by Freeman L.J., et al. Fibulin-5 interacts with fibrillin-1 molecules and microfibrils.