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- Table of Contents
Facts about rRNA 2'-O-methyltransferase fibrillarin.
Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.
Human | |
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Gene Name: | FBL |
Uniprot: | P22087 |
Entrez: | 2091 |
Belongs to: |
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methyltransferase superfamily |
EC 2.1.1,34-kD nucleolar scleroderma antigen; EC 2.1.1.-; EC 2.1.1.37; FIB; FIB1,34 kDa nucleolar scleroderma antigen; fibrillarin; FLRNrRNA 2'-O-methyltransferase fibrillarin; RNA, U3 small nucleolar interacting protein 1; RNU3IP1
Mass (kDA):
33.784 kDA
Human | |
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Location: | 19q13.2 |
Sequence: | 19; NC_000019.10 (39834458..39846395, complement) |
Nucleus, nucleolus. Fibrillar region of the nucleolus.
PMID: 1846968 by Aris J.P., et al. cDNA cloning and sequencing of human fibrillarin, a conserved nucleolar protein recognized by autoimmune antisera.
PMID: 2026646 by Jansen R.P., et al. Evolutionary conservation of the human nucleolar protein fibrillarin and its functional expression in yeast.