E3 ubiquitin-protein ligase FANCL (FANCL)

Ubiquitin ligase protein that mediates monoubiquitination of FANCD2 in the presence of UBE2T, a key step in the DNA damage pathway (PubMed:12973351, PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:24389026). Also mediates monoubiquitination of FANCI (PubMed:19589784).

May stimulate the ubiquitin release from UBE2W. May be required for appropriate primordial germ cell proliferation in the embryonic phase, whereas it is probably not needed for spermatogonial proliferation after birth.