FAAH Antibodies

Fatty-acid amide hydrolase 1 (FAAH)

Degrades bioactive fatty acid amides such as oleamide, the endogenous cannabinoid, anandamide and myristic amide to their amino acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially compared to monounsaturated substrates.

.

Gene Information

Human
Gene Name:	FAAH
Uniprot:	O00519
Entrez:	2166

Family

Belongs to:
amidase family

Alternative Names

Anandamide amidohydrolase 1; EC 3.5.1; EC 3.5.1.99; EC 3.5.1.n2; FAAH1; FAAH-1; fatty acid amide hydrolase; fatty-acid amide hydrolase 1; MGC102823; MGC138146; Oleamide hydrolase 1

Molecular Weight

Mass (kDA):
63.066 kDA

Genomic Context

Human
Location:	1p33
Sequence:	1; NC_000001.11 (46394317..46413845)

Tissue Specificity

Highly expressed in the brain, small intestine, pancreas, skeletal muscle and testis. Also expressed in the kidney, liver, lung, placenta and prostate.

Subcellular Localizations

Endomembrane system; Single-pass membrane protein. Cytoplasm, cytoskeleton. Seems to be attached to intracellular membranes and a portion of the cytoskeletal network.

Diseases

• Pain
• Inflammation
• Nervousness
• Obesity
• Anxiety Disorders
• Hyperalgesia
• Depressive Disorder
• Neuralgia
• Malignant Neoplasms
• Neuroblastoma
• Neoplasms

• Leukemia
• Substance Withdrawal Syndrome
• Stress, Psychological
• Glioma
• Basophilic Leukemia
• Catalepsy

Interacting Proteins

• NOTCH2NL

Pathways

• Transport
• Localization
• Cell Proliferation
• Embryo Development
• Secretion
• Pathogenesis
• Cell Death
• Cognition
• Hypersensitivity
• Methylation
• Neuroprotection
• Acrosome Reaction
• Neurogenesis

• Vasodilation
• Synaptic Transmission
• Cell Activation
• Spermatogenesis
• Gastric Emptying
• Cellular Localization
• Fertilization

PTMs

• Cleavage
• Phosphorylation
• Oxidation
• Methylation
• Amidation
• Hydroxylation

• Carbamylation
• Acylation
• Decarboxylation
• Acetylation
• Dephosphorylation
• Ubiquitination

Research Areas

• Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FAAH

Boster Bio: Best Uses Of The FAAH Marker

You're interested in Boster and what they can offer you for your research? Continue reading. This article will cover Boster's history, the Products they provide, and their most effective applications for the FAAH Marker. Anyone who is interested in the FAAH Marker will find this information useful. It's a fantastic resource for researchers on a variety of species which include cows, pigs sheep, humans, and pigs.

The background of Boster

Steven Boster's first product which was a kit for IHC, was developed in 1993. He had already created hundreds of primary antibodies by the end of the decade and was the largest catalog antigen company in China. His own ELISA platform, PicoKine(tm), was also developed. This platform uses trade secrets to deliver high-sensitivity ELISA kit kits. Boster's biography outlines the history of the company, including its beginnings in Blandford Forum (Dorset).

The book is divided into three sections that each focus on a different aspect of slavery in America's south. The first, which is devoted to the lives of fugitive slave Tom Wilson, focuses on his story and how it was used in propaganda for abolitionists. The book also contains historical records as well as song lyrics, lithographs and artifacts from slavery.

Products offered by Boster Bio

Boster Bio has over 16,000 antibodies on hand. Many of them have been validated for IHC, WB, ELISA and FC. They provide rabbit polyclonal antibody and a complimentary secondary antibody when you purchase their primary antibody. Their products can be used on human or mouse samples and are guaranteed to maintain biological activity. If you have any concerns or questions you can contact Boster Bio customer service or visit their website. They can offer a customized service and BeNeLux delivery.

Established in 1993, Boster Bio is a manufacturer of antibodies and ELISA products. Recently, they have expanded into molecular biology, as well as related products for PCR. Scientists will find Boster's customer support extremely helpful. Boster offers technical assistance 24 hours per day and free technical support. You can trust their products to be the top of the line. You can rest assured that their products are of the highest standard because they are produced by them.

Boster Biologicals produces antibody kits and biomarker detection antibodies. They can be used for western blotting and immunohistochemistry. The company also provides services such as custom mouse monoclonal antibodies, recombinant protein expression assays, and multiplex cytokine assays. The company's antibodies can detect biomarkers at the picogram level, which makes them an effective tool in cancer research.

Boster Bio products are of the highest quality and contain recombinant protein. They are extremely specific, and have been tested for IHC, WB, and Flow cytometry. Boster Bio has over 29,000 publications that have cited their products, and every product comes with a Boster Quality Guarantee, which guarantees that it will perform as promised. Alongside high-quality products, Boster Bio also stands by the quality of their Reagents.

Applications of the FAAH Marker

The FAAH marker is extremely sensitive and precise test for the detection of fat acids amides. This enzyme hydrolyzes fatty acids in the body, and then stops their signaling functions. FAAH is found primarily in the brain, small intestine and testis. It is inhibited by alpha-keto heterocytes as well as O-aryl carbamates. It belongs to the amidase family.

Sepsis is an inflammatory disease that involves a disordered immune system response and degrading of organ function. AEA overexpression is the hallmark for septic pathogenesis. FAAH enzyme is involved with the hydrolysis of AEA. FAAH is expressed in greater quantities in healthy donors that in patients suffering from sepsis. Its level could be a biomarker to predict the development of septic shock.

Adeno-associated viruses (AAV) were overexpressed FAAH hippocampal CA1–CA3 neurons that produce glutamatergic signals. This treatment inhibited AEA signaling and decreased anxiety. Additionally, FAAH was found in glial cells. This study confirms that FAAH is involved in the control of glutamatergic nerve transmission and the regulation of anxiety. The AAV-Glu-FAAH mice showed decreased index of recognition as well as total exploration time and locomotion when performing a spatial object recognition task. Another study examined the latency to enter dark chambers and assessed the effects of aversive memories. After the memory acquisition test was completed, the time required to enter the dark chamber was not affected by AAV-Glu/FAAH mice.

A recent study showed that inhibition of FAAH reduced the growth of cells in EC and other types of cells. URB597 (uroyl-bourdon-bourbon) treatment had no effect on Ki67+ cells or native cells. In contrast, DMSO solvent control had no effect. It was difficult to translate in vitro concentrations to an in-vivo setting. Further studies are needed to confirm the effectiveness of FAAH inhibition.

The FAAH marker is employed in a variety of angiogenesis areas. This gene blocks the cell cycle exit of EC cells and reduces their proliferation, leading to decreased angiogenesis. The inhibition of angiogenesis has anti-angiogenic properties. Its potential beneficial effects on tumor-related angiogenesis may be due to its inhibiting properties. If it is effective, FAAH inhibition could help treat patients suffering from blood clots.

The FAAH Marker is related to diminished angiogenesis and vascular growth. FAAH inhibitors are used to prevent choroidal neovascularization as well as vascular Neovascularization. The FAAH-inhibition-induced antiangiogenic responses were not mediated by cannabinoid receptors or TRPV1 activation. FAAH instead blocks the lipid-rafts.