Coagulation factor VII Antibodies

Coagulation factor VII (F7)

Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form.

Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis.

Gene Information

Human
Gene Name:	F7
Uniprot:	P08709
Entrez:	2155

Family

Belongs to:
peptidase S1 family

Alternative Names

coagulation factor VII (serum prothrombin conversion accelerator); Coagulation Factor VII; EC 3.4.21; EC 3.4.21.21; Eptacog alfa; F7; FVII coagulation protein; proconvertin; Serum prothrombin conversion accelerator; SPCA

Molecular Weight

Mass (kDA):
51.594 kDA

Genomic Context

Human
Location:	13q34
Sequence:	13; NC_000013.11 (113105773..113120685)

Tissue Specificity

Plasma.

Subcellular Localizations

Secreted.

Diseases

• Factor Vii Deficiency
• Malignant Neoplasms
• Hemorrhage
• Plant Diseases
• Neoplasms
• Cardiovascular Diseases
• Depressive Disorder
• Tissue Adhesions
• Heart Diseases
• Dysequilibrium Syndrome
• Infective Disorder
• Coronary Heart Disease
• Blood Coagulation Disorders

• Thrombosis
• Infarction
• Epilepsy
• Myocardial Infarction
• Schizophrenia
• Hypertensive Disease
• Carcinoma

Interacting Proteins

• F3

Pathways

• Coagulation
• Localization
• Secretion
• Pathogenesis
• Hemostasis
• Transport
• Translation
• Cell Death
• Reflex
• Mating
• Aging
• Immune Response
• Virulence

• Platelet Aggregation
• Blood Coagulation
• Cell Migration
• Interphase
• Cognition
• Disease Resistance
• Regeneration

PTMs

• Cleavage
• Phosphorylation
• Reduction
• Gamma-carboxylation
• Oxidation

• Methylation
• Nitration
• Carboxylation
• Glycosylation
• Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/F7

Boster Bio: Best Uses of the F7 Marker

For scientists, the Boster Bio: Best Uses of the F7 marker is a perfect tool for the work they do every day. Its versatility allows scientists the ability to submit results from special samples, species, and applications. Scientists across the world can use this marker to test various substances. They may also be eligible for product credits. Here are some useful applications for scientists:

Anti-von Willebrand Factor / Factor VIII Related Ag

Von Willebrand factor, a multimeric plasma glycoprotein, mediates platelet adhesion to damaged vessel walls. It is also a carrier for and stabilizer for coagulation factors VIII. It contains functional binding domains that are compatible with platelet glycoprotein Ib or collagen. This factor is also expressed when there are tumors of vascular source. Hence, it is recommended for use in adjunctive immunohistopathology.

The VWF Monoclonal Antibody is catalog number M00270 and reacts with Human. The antibody is non-hazardous. The product can be prepared in 10mM PBS with 0.05% BSA or azide. You can also purchase blocking Peptides of 1.0 mg/ml. This company also validates its antibodies against known negative and positive samples.

Detecting von Willebrand disease is difficult. The cause of the disease is not known. It has been shown to have the ability to stabilize factor VIII coagulant activities and platelet adhesion to subendothelial tissues. It can also contribute to platelet accumulation when it is in contact with an antibiotic.

Hemophilia A is not affected by inhibitory alloantibodies. It is about 15% in severe hemophilia patients. Many inhibitors within the clinical spectrum are transient, and can be reversed. Therefore, the use of Anti-VWF in patients with hemophilia A is limited, because patients may develop inhibitors after the first exposure.

Endothelial Marker

The F7 endothelial marker is used in many areas of medicine and biological science. It can be used to differentiate between healthy and sick blood vessels. The F7 marker, a common protein found within the endothelium in various tissues, such as the lungs, is also known. It isn't used widely, despite its importance. Scientists are still trying to determine the role of this drug in the development and use of cancer drugs.

F7 cells were grown at 37 degrees Celsius and 5% CO2 in MC-MEFs. After five days of cultivation, the cells were broken down by TrypLE. The cells were then fixed at 21 to 26 degC with 4% Paraformaldehyde. The cells were then incubated with the staining solutions for 30 minutes at ambient temperature. After dissociation, cells were stained with AP chromogenic stain.