Tissue factor Antibodies

Tissue factor (F3)

Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis.

TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. .

Gene Information

Human
Gene Name:	F3
Uniprot:	P13726
Entrez:	2152

Family

Belongs to:
tissue factor family

Alternative Names

CD142 antigen; CD142; coagulation factor III (thromboplastin, tissue factor); Coagulation Factor III; F3; FLJ17960; TF; TFA; Thromboplastin; Tissue Factor

Molecular Weight

Mass (kDA):
33.068 kDA

Genomic Context

Human
Location:	1p21.3
Sequence:	1; NC_000001.11 (94529173..94541857, complement)

Tissue Specificity

Lung, placenta and pancreas.

Subcellular Localizations

[Isoform 1]: Membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.

Diseases

• Fibrosis
• Liver Cirrhosis
• Hepatitis
• Hepatic Fibrosis
• Hepatitis C
• Neoplasms
• Hepatitis, Chronic
• Hepatitis C, Chronic
• Tissue Adhesions
• Malignant Neoplasms
• Leukemia
• Liver Diseases

• Carcinoma
• Hepatitis B
• Liver Carcinoma
• Nervousness
• Depressive Disorder
• Plant Diseases
• Myeloid Leukemia

Interacting Proteins

• F2RL1
• F7

Pathways

• Cell Proliferation
• Cell Adhesion
• Secretion
• Localization
• Cell Growth
• Ovulation
• Cell Cycle
• Transport
• Methylation
• Cell Death
• Immune Response
• Pathogenesis
• Mating

• Coagulation
• Lactation
• Aging
• Glycosylation
• Myelination
• Cell Migration
• Fertilization

PTMs

• Phosphorylation
• Cleavage
• Methylation
• Glycosylation
• Reduction
• Acetylation
• Ubiquitination
• Biotinylation
• Oxidation
• Deglycosylation

• Gpi Anchoring
• Nitration
• Deacetylation
• Hydroxylation
• Dephosphorylation
• Acylation
• Iodination
• Myristoylation
• Sulphation
• Sumoylation

Research Areas

• Cancer

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/F3

Best Uses Of The F3 Marker For Biomarker Applications

If you're planning to utilize the F3 marker in biomarker-related applications, you need to know how this technology functions. It is used to make high-affinity primary antibodies. This technology can be used to capture many molecules which include antiviral antibodies. This guide can help make your experiment more efficient if you are applying for a grant from the NIH to finance biomarker funding.

Funding for Boster Bio

As part of their ongoing support for undergraduate research, Boster Biological Technology has recently announced an opportunity for scholarships for college students. Known as the BosterBio Scholarship Fund, the award is designed to assist students overcome the financial obstacles of attending college. The scholarship will provide one student with a $1,000 grant and requires evidence of an academic job. To be eligible students must have completed at least nine credits of research in order to be considered for this award.

Boster Bio manufactures its own antibodies and ELISA kits, ensuring that they are of the highest standard. Boster Bio's unique coatings and blocking technologies guarantee consistent results across a variety of samples and many samples. All of their products are validated against real tissues and recombinant proteins in order to meet the strictest quality standards. They also have a robust technical support network that can offer guidance and assistance to researchers and scientists. Boster Bio can help you make the most out of your new antibody. Contact us today to find out how we can enhance your research and make it easier for you to manage your time!

Boster Bio was founded in 1993 by renowned histologist Steven Xia, a renowned expert in the field of histology. Their products are cited in more than 23,000 scientific articles. Boster Bio antibodies have been tested thoroughly for multiple applications and come with a Boster Quality Guarantee. The range of antibodies is growing each month. Contact us today if are interested in funding Boster Bio to learn more about our award-winning products and services.

Information about high-affinity primary antibodies

High-affinity primary antibodies perform better in assays , and also have greater binding affinity. The higher the affinity the more specific an antibody is. High affinity antibodies bind to antigens quickly and strongly. This allows them to identify multiple epitopes with one assay. Furthermore, high affinity antibodies can keep a strong connection even under demanding conditions. Low-affinity antibody, on the contrary, are ineffective against some antigens and can often not detect the antigen in vivo or by tests.

Because antibodies can be produced against a variety of epitopes The genome of an organism would need to grow exponentially if it was to code for every single antigen-binding site. But, B-cells are able to adapt to this situation by way of somatic hypermutation. Somatic hypermutation triggers the genes responsible for coding for the antigen-binding site to undergo rapid changes. In this manner, successive generations of B cell lines are exposed to the antigen. Only those cells with high affinity remain. This process is referred to as affinity maturation.

Variable domains can be found in Chlamydia-specific antibodies. The a-2-eight-linked disaccharide in the LPS is the antigen these antibodies recognize. S25-23 for instance recognizes the terminal region of the chlamydial LPS. Other antigens have similar structures, however they differ in the amino acid sequence of the CDR-loops.

Analyzing the molecular structure of anti-carbohydrate antibodies has shown that the genetic composition of the S25-23 antibody, the most widely used primary antibody found in the human immune system, has different properties than other carbohydrate antigens. The dissociation constants for high-affinity primary antibodies tend to be higher than those for carbohydrate antigens. The preference for trisaccharide antibody is a further characteristic of the S25/23 antibody. The S2523 antibody showed very little or no binding for other glycoconjugates.

Therapeutic mAbs may be used in humans to treat autoimmune conditions and aid in pregnancy. These antibodies have not been utilized in pregnancy for a long time due to their limited experience. They are usually of the class IgG1, which accumulates within the fetus. The risk of side effects is minimal. There are many kinds of mAbs which can be used during pregnancy.

One type of high-affinity primary antibody is known as L19. It recognizes the ED-B domain of fibronectin. The antibody is highly targeted towards tumor cells and is located within the tissues that contain it. The antibody is also efficient at clearing the tumor. It has a blood-to-tumor ratio (Blood-to-Tumor Ratio) of 1.9, 3.7, and 11.8 at three to five hours, five to 24 hours, and 11.8 at 24 hours. The effectiveness of L19's tumor-targeting abilities in the 0.7-10 mg range is not dependent on dose.

Tips for optimizing your NIH grant applications

The NIH has guidelines that will assist you in preparing your materials to submit a grant application. Its guidelines are available at the NIH Guide for Grants and Contracts. The NIH Grants Policy Statement regulates grant awards. The grant-making procedure at the NIH is under the control of the Public Health Service Act, 42 USC 241 & 284, and Federal Regulations, 42 CFR 52 and 45 CFR Part 75.

When applying for NIH grants, applicants must be aware of the following factors: Therapeutic leads applicants need to have a properly profiled clinically relevant lead. Initial findings should suffice for research that can be IND-enabling. It is not likely that bioactive agents with a low profile or too many optimization parameters will be accepted in the program. To further develop the drug, companies must submit a research grant.

NIH biosketches must adhere to the predefined format. Both applicants and recipients can utilize the NIH format pages to format biosketches. You can also utilize a software to automatically format your biosketch, like SciENcv, which can create an attractive biosketch that is formatted correctly. These tips will allow you to maximize the value of your NIH grant application. However, it is important to keep them in mind.