ENPP3 Antibodies

AND ENPP3 ELISA kits, ENPP3 Proteins

Many biological assays use antibodies to detect ENPP3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ENPP3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ENPP3 antibodies...

We validate the specificity of these antibodies to ENPP3 by testing them on tissues known to express ENPP3 positively and negatively. Browse below to find the ENPP3 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: CBLIF Next: PDYN

ENPP3 Infographic by Boster Bio

All ENPP3 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-CD203c ENPP3 Antibody

1 Citations 5 Q&As

Human, Mouse, Rat

ELISA, IHC-P, WB

$399
Cat # A05615
100μl

Anti-Hu CD203c Purified ENPP3 Monoclonal Antibody

Human

Flow Cytometry, ICC

$315
Cat # M05615
0.1 mg

ENPP3 (NM_005021) Human Over-expression Lysate

Human

$960
Cat # LS005169
100 µg

ENPP3 Overview

Facts about Ectonucleotide pyrophosphatase/phosphodiesterase family member 3.

ENPP3 3D structure. Source: alphafold

Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3)

Hydrolase that metabolizes extracellular nucleotides, such as ATP, GTP, UTP and CTP (PubMed:29717535). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic reactions by eliminating the extracellular ATP that acts as signaling molecule and triggers basophils and mast cells and induces the release of inflammatory cytokines.

Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells (By similarity). Has also alkaline phosphodiesterase activity (PubMed:11342463).

Gene Information

Human
Gene Name:	ENPP3
Uniprot:	O14638
Entrez:	5169

Family

Belongs to:

nucleotide pyrophosphatase/phosphodiesterase family

Alternative Names

B10; CD203c antigen; CD203c; dJ1005H11.3 (phosphodiesterase I/nucleotide pyrophosphatase 3); dJ914N13.3 (phosphodiesterase I/nucleotide pyrophosphatase 3); ectonucleotide pyrophosphatase/phosphodiesterase 3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3; E-NPP 3; ENPP3; ENPP-3; gp130RB13-6; NPP3; PD-IBETA; PDNP3; PDNP3B10; Phosphodiesterase I beta; Phosphodiesterase I/nucleotide pyrophosphatase 3; phosphodiesterase-I beta

Molecular Weight

Mass (kDA):
100.124 kDA

Genomic Context


Human

Location:	6q23.2
Sequence:	6; NC_000006.12 (131637302..131747413)

Tissue Specificity

Detected on bile ducts in liver, and in blood serum (at protein level) (PubMed:15072822). Detected in prostate and uterus (PubMed:9344668). Detected on basophils, but not neutrophils (PubMed:11342463).

Subcellular Localizations

Cell membrane; Single-pass type II membrane protein. Apical cell membrane; Single-pass type II membrane protein. Secreted. Detected at the cell surface of basophils (PubMed:11342463). Detected at the apical plasma membrane of bile duct cells (PubMed:15072822). Located to the apical surface in intestinal and kidney epithelial cells. Secreted in serum, and in lumen of epithelial cells.

Diseases

Allergy
Anaphylaxis
Hay Fever
Food Allergy
Urticaria
Immediate Hypersensitivity
Asthma
Neoplasms
Inflammation
Urticaria Chronic
Mastocytosis

Malignant Neoplasms
Carcinoma
Autoimmune Diseases
Latex Allergy
Milk Hypersensitivity
Allergy To Peanuts

Pathways

Basophil Activation
Sensitization
Anaphylaxis
Localization
Hypersensitivity
Cell Activation
Secretion
Basophil Degranulation
Histamine Secretion
Cytokine Production
Transport
Intracellular Transport
Immune Response

Leukocyte Differentiation
Intracellular Signal Transduction
Transcytosis
Outflow Tract Morphogenesis
Biosynthetic Process
Glomerular Filtration
Tissue Remodeling

PTMs

Glycosylation

Cleavage

Phosphorylation

Research Areas

Protein Phosphatase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ENPP3

References

PMID: 9344668 by Piao J.-H., et al. Molecular cloning and chromosomal localization of PD-Ibeta (PDNP3), a new member of the human phosphodiesterase I genes.

PMID: 11342463 by Buehring H.J., et al. The basophil activation marker defined by antibody 97A6 is identical to the ectonucleotide pyrophosphatase/phosphodiesterase 3.

1 Publications of Boster ENPP3 Antibodies & ELISA Kits

PubMed ID: 10.1002/pmic.201700443, Impacts of Dietary Pleurotus eryngii Polysaccharide on Nutrient Digestion, Metab...

*More publications can be found for each product on its corresponding product page