EMG1 Antibodies

AND EMG1 ELISA kits, EMG1 Proteins

Many biological assays use antibodies to detect EMG1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with EMG1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop EMG1 antibodies...

We validate the specificity of these antibodies to EMG1 by testing them on tissues known to express EMG1 positively and negatively. Browse below to find the EMG1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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EMG1 Infographic by Boster Bio

All EMG1 Products

Product

Figures

Specificity

Applications

Price

EMG1 (NM_006331) Human Recombinant Protein

$1249
Cat # PROTQ92979
20 µg

Anti-EMG1 Mouse Monoclonal Antibody [Clone ID: OTI1B8]

Dog, Human, Monkey, Mouse, Rat

Flow Cytometry, IF, WB

$523
Cat # M08458
100 µl

EMG1 (NM_006331) Human Over-expression Lysate

Human

$628
Cat # LS010436
100 µg

EMG1 Overview

Facts about Ribosomal RNA small subunit methyltransferase NEP1.

EMG1 3D structure. Source: alphafold

Ribosomal RNA small subunit methyltransferase NEP1 (EMG1)

S-adenosyl-L-methionine-dependent pseudouridine N(1)- methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.

Is unable to methylate uridine at this position (PubMed:20047967). Has also an essential part in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 through the formation of pre-ribosomes (By similarity).

Gene Information

Human
Gene Name:	EMG1
Uniprot:	Q92979
Entrez:	10436

Family

Belongs to:

class IV-like SAM-binding methyltransferase superfamily

Alternative Names

18S rRNA (pseudouridine-N1-)-methyltransferase NEP1; BWCNS; C2F18S rRNA Psi1248 methyltransferase; EMG1 nucleolar protein homolog (S. cerevisiae); essential for mitotic growth 1; FLJ60792; Grcc2f; NEP1EC 2.1.1.-; Nucleolar protein EMG1 homolog; probable ribosome biogenesis protein NEP1; Protein C2f; Ribosome biogenesis protein NEP1

Molecular Weight

Mass (kDA):
26.72 kDA

Genomic Context


Human

Location:	12p13.31
Sequence:	12; NC_000012.12 (6970913..6997428)

Subcellular Localizations

Nucleus, nucleolus.

Diseases

Psychomotor Disorders
Fetal Growth Retardation
Developmental Disabilities
Malignant Neoplasms
Neoplasms
Hiv Infections

Interacting Proteins

FAM74A4

Pathways

Ribosome Biogenesis
Ribosome Assembly
Methylation
Nucleologenesis
Regulation Of Cell Cycle
Cell Proliferation
Localization
Cell Cycle Arrest
Embryo Development
Cell Cycle

Rrna Methylation
Cell Growth
Rna Processing
Rrna Processing

PTMs

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EMG1

References

PMID: 9074930 by Ansari-Lari M.A., et al. Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination.

PMID: 11935223 by Eschrich D., et al. Nep1p (Emg1p), a novel protein conserved in eukaryotes and archaea, is involved in ribosome biogenesis.