ELOVL4 Antibodies

Elongation of very long chain fatty acids protein 4 (ELOVL4)

Catalyzes the first and rate-limiting reaction of the four which constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic procedure, allows the addition of two carbons into the string of long- and very long-chain fatty acids/VLCFAs each cycle.

Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate in the production of polyunsaturated and saturated VLCFAs of different chain lengths which are involved in several biological processes as precursors of membrane lipids and lipid mediators.

Gene Information

Human
Gene Name:	ELOVL4
Uniprot:	Q9GZR5
Entrez:	6785

Family

Belongs to:
ELO family

Alternative Names

Elongation of very long chain fatty acids protein 4

Molecular Weight

Mass (kDA):
36.829 kDA

Genomic Context

Human
Location:	6q14.1
Sequence:	6; NC_000006.12 (79914814..79947553, complement)

Tissue Specificity

Expressed in the retina and at much lower level in the brain. Ubiquitous, highest expression in thymus, followed by testis, small intestine, ovary, and prostate. Little or no expression in heart, lung, liver, or leukocates.

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Diseases

• Stargardt disease 3 (STGD3)

PTMs

• Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ELOVL4

Best Uses Of The ELOVL4 Marker

The ELOVL4Marker belongs to a large number of fatty-acid elongases. It is localized in interneurons of the polymorph layer and expressed in the somatic SER. Its presence in the bloodstream and CNS suggests it is a good candidate for use in the diagnosis of CNS disease. This article will cover the uses and potential of the ELOVL4 indicator as a biomarker.

ELOVL4 belongs to a large group of fatty acid elongases.

The ELOVL elongases are responsible for a number of biological functions. These functions include the CNS function, epidermal blood barrier and systemic metabolic processes. Some members of this family are also associated with neurological disease. CNS health and function are dependent on fatty acid elongation. There are many other uses for the ELOVL elongases family.

ELOVL4 plays a role in the biosynthesis and maintenance of neuronal health. It produces VLC-PUFAs, which can be converted to phosphatidylcholine as well as "elovanoid", which help photoreceptors stay alive. ELOVL4 products are abundant within synaptic vesicles, and play an important part in neurotransmitter releases.

ELOVL4 represents neural development. Its expression is high at birth but gradually decreases as the brain grows. It reaches a steady state by the 30th postnatal day in mice. In mice, immunolabeling studies have shown that ELOVL4 expression is high in the subventricular zone and dentate gyrus. It also appears in the internal and exterior granular layers of cerebellum. However, its expression decreases as neurogenesis decreases. ELOVL4 is therefore thought to play a key role in neurogenesis.

The ELOVL4 protein encodes a protein that elongates PUFA and SFa long chains. There are two types of ELOVL family members that perform this function. Three different human diseases have been linked to the ELOVL4 gene. These diseases include Stargardt-like macular degeneration and spinocerebellar aphasia 34.

ELOVL4 gene expression is primarily neuronal. However, there have been reports of small ELOVL4-positive cells in white matter. This suggests that ELOVL4 can also be found in oligodendrocytes. NeuN and ELOVL4 are also found in many tissues, such as the HPF cellular layers. Further, ELOVL4 is highly expressed in brains that utilize glutamate and GABAergic neurotransmitters.

ELOVL4 is well-known for producing VLC-SFA compounds, which can be used as membrane stabilisers, anchor points for proteins, or lipid raft components. It is also known for its ability stimulate VLC-PUFA releasing, which can help researchers understand this bioactive. Boster Bio's ELOVL4 product might be a good choice if you're looking to find a high-quality VLC PUFA marker.

It is expressed in the somatic SER

The expression of ELOVL4 is highly conserved in the adult testis of the rat. Elovl4 is one member of the Elovl4 family. Elovl2 and Elovl5 are two members. All of these genes are expressed at high levels in the STs. Elovl4 was absent in the testes during the early stages of postnatal growth, but it was found to be present in the adult testis at a high level. This protein has a high expression in the RS (LS) and RS (RS), suggesting that it is a functional gene.

During embryonic development, Elovl4 expression was strongly detected in PtSs and RSs. The mRNA coding the Elovl4 gene decreased in PtS and RS in order to detect LS. However, it returned to adult levels by the end of spermatozoon. Elovl4's mRNA and protein expression was found to correlate with somatic spermatozoa levels of hVs and nVs.

RTPCR was used to study the cells of other types of epitheliums, including those in the seminiferous. Elovl family members were also investigated. Elovl6 had the highest mRNA, while Elovl7 was only detected in the somatic SE. Elovl1 & Elovl4 are active in germ cells. The results from RTPCR analysis have confirmed that ELOVL4 has been expressed in the somatic SER.

The presence or absence of an agent in somatic tissues can cause ELOVL4's expression to increase. This agent can be a small organic molecule such as a RNA or DNA binding ligand, or a large organic molecule like polyethylene glycol. These agents induce the expression and function of the reprogramming elements in the somatic SSER. This process could also occur in different cell types. ELOVL4 has been found in the somatic SER, rat brain.

It is located in the interneurons in polymorph layer

In order to test the hypothesis that ELOVL4 is localized in the polymorph layer of the brain, the scientists first looked at the structure of ELOVL4 in the human hippocampus. These results confirmed that ELOVL4 is a component of the interneurons in this layer. The ELOVL4 protein, a phosphoprotein, is located in the Boster Bio polymorph layer.

It is a potential biomarker of CNS disease

ELOVL4 is a gene that provides instructions for making a protein found in the retina, a specialized light-sensitive tissue. It is also present in the brain and skin. The stability of the blood-brain border is a key function of the ELOVL4 gene in mice. It is not yet clear if ELOVL4 can be used as a biomarker for CNS diseases.

Genetic studies have linked the gene to Stargardt type macular dystrophy through genetic studies of ELOVL4-related gene mutations. However, the mechanism by which ELOVL4 mutations cause the disease remains unclear. This protein is found within the retina and in other tissues, such as the testis, thymus and skin. Molecular analysis has shown mutations in ELOVL4 can lead to the deposition of fatty acid longer than 26 carbons.