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- Table of Contents
Facts about Elongation of very long chain fatty acids protein 4.
Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate in the production of polyunsaturated and saturated VLCFAs of different chain lengths which are involved in several biological processes as precursors of membrane lipids and lipid mediators.
Human | |
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Gene Name: | ELOVL4 |
Uniprot: | Q9GZR5 |
Entrez: | 6785 |
Belongs to: |
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ELO family |
Elongation of very long chain fatty acids protein 4
Mass (kDA):
36.829 kDA
Human | |
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Location: | 6q14.1 |
Sequence: | 6; NC_000006.12 (79914814..79947553, complement) |
Expressed in the retina and at much lower level in the brain. Ubiquitous, highest expression in thymus, followed by testis, small intestine, ovary, and prostate. Little or no expression in heart, lung, liver, or leukocates.
Endoplasmic reticulum membrane; Multi-pass membrane protein.
PMID: 11138005 by Zhang K., et al. A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy.
PMID: 11581213 by Edwards A.O., et al. A novel gene for autosomal dominant Stargardt-like macular dystrophy with homology to the SUR4 protein family.