Egl nine homolog 3 Antibodies

AND Egln3 ELISA kits, Egl nine homolog 3 Proteins

Many biological assays use antibodies to detect Egl nine homolog 3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Egl nine homolog 3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Egl nine homolog 3 antibodies...

We validate the specificity of these antibodies to Egl nine homolog 3 by testing them on tissues known to express Egln3 positively and negatively. Browse below to find the Egln3 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Egln3 Infographic by Boster Bio

All Egln3 Products

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Product

Figures

Specificity

Applications

Price

Human EGLN3/PHD3 Recombinant Protein

SDS-PAGE

$275
Cat # PROTQ9H6Z9
Starting from 10ug

Anti-PHD3 Rabbit Monoclonal Antibody

Human, Mouse, Rat

IP, IF, ICC, WB

$370
Cat # M02182
100 μl/vial

PHD3 (EGLN3) (NM_022073) Human Over-expression Lysate

Human

$628
Cat # LS112399
100 µg

Egln3 Overview

Facts about Egl nine homolog 3.

Egl nine homolog 3 (Egln3)

Plays a crucial role in DNA damage response (DDR) by hydroxylating TELO2, boosting its interaction with ATR which is necessary for activation of the ATR/CHK1/p53 pathway (By similarity). Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha cells.

Hydroxylates a particular proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Has a preference for the CODD website for both HIF1A and HIF2A.

Gene Information

Rat
Gene Name:	Egln3
Uniprot:	Q62630
Entrez:	54702

Family

Belongs to:

No superfamily

Alternative Names

EC 1.14.11; EC 1.14.11.-; EGL nine (C.elegans) homolog 3; egl nine homolog 3 (C. elegans); egl nine homolog 3; egl nine-like protein 3 isoform; EGLN3; FLJ21620; HIF prolyl hydroxylase 3; HIFPH3 MGC125998; HIFPH3; HIF-PH3; HIF-prolyl hydroxylase 3; HPH-1; HPH-3; Hypoxia-inducible factor prolyl hydroxylase 3; MGC125999; pdh3; PHD3; Prolyl hydroxylase domain-containing protein 3

Molecular Weight

Mass (kDA):
27.242 kDA

Genomic Context


Rat

Location:	6q23
Sequence:	6;

Tissue Specificity

Highly expressed in vascular smooth muscle. Moderately expressed in esophagus, stomach, small bowel and aorta. Low levels in tail and kidney. Expression also in pheochromocytoma cell line PC-12.