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- Table of Contents
Facts about Eyes absent homolog 4.
Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its role as histone phosphatase probably explains its role in transcription regulation during organogenesis.
Human | |
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Gene Name: | EYA4 |
Uniprot: | O95677 |
Entrez: | 2070 |
Belongs to: |
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HAD-like hydrolase superfamily |
CMD1J; DFNA10; dJ78N10.1 (eyes absent); EC 3.1.3.48; eyes absent (Drosophila) homolog 4; eyes absent homolog 4 (Drosophila); eyes absent homolog 4
Mass (kDA):
69.505 kDA
Human | |
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Location: | 6q23.2 |
Sequence: | 6; NC_000006.12 (133240340..133532128) |
Highly expressed in heart and skeletal muscle.
Cytoplasm. Nucleus.
PMID: 9887327 by Borsani G., et al. EYA4, a novel vertebrate gene related to Drosophila eyes absent.
PMID: 11159937 by Wayne S., et al. Mutations in the transcriptional activator EYA4 cause late-onset deafness at the DFNA10 locus.