Exostosin-like 2 Antibodies

AND EXTL2 ELISA kits, Exostosin-like 2 Proteins

Many biological assays use antibodies to detect Exostosin-like 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Exostosin-like 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Exostosin-like 2 antibodies...

We validate the specificity of these antibodies to Exostosin-like 2 by testing them on tissues known to express EXTL2 positively and negatively. Browse below to find the EXTL2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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EXTL2 Infographic by Boster Bio

All EXTL2 Products

Product

Figures

Specificity

Applications

Price

EXTL2 (NM_001439) Human Recombinant Protein

$1249
Cat # PROTQ9UBQ6
20 µg

EXTL2 (NM_001439) Human Over-expression Lysate

Human

$628
Cat # LS002135
100 µg

EXTL2 Overview

Facts about Exostosin-like 2.

EXTL2 3D structure. Source: alphafold

Exostosin-like 2 (EXTL2)

Glycosyltransferase required for the biosynthesis of heparan-sulfate and accountable for its alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N- acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. .

Gene Information

Human
Gene Name:	EXTL2
Uniprot:	Q9UBQ6
Entrez:	2135

Family

Belongs to:

glycosyltransferase 47 family

Alternative Names

Alpha-1,4-N-acetylhexosaminyltransferase EXTL2; alpha-1,4-N-acteylhexosaminyltransferase; Alpha-GalNAcT EXTL2; EC 2.4.1.223; exostoses (multiple)-like 2; Exostosin like 2; Exostosin-like 2; EXTL2; EXTR2; EXT-related protein 2; Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; processed exostosin-like 2

Molecular Weight

Mass (kDA):
37.466 kDA

Genomic Context


Human

Location:	1p21.2
Sequence:	1; NC_000001.11 (100872372..100895411, complement)

Tissue Specificity

Ubiquitous.

Subcellular Localizations

Endoplasmic reticulum membrane; Single-pass type II membrane protein.; [Processed exostosin-like 2]: Secreted. A soluble form is found in the serum.

Diseases

Hereditary Multiple Exostoses
Exostoses
Neoplasms
Bone Diseases
Bone Neoplasms
Cartilaginous Exostosis
Trematode Infections
Hereditary Diseases
Malignant Paraganglionic Neoplasm
Fibroma
Malignant Neoplasm Of Breast
Sarcoma

Mucopolysaccharidoses
Fibrosis
Multiple Myeloma
Chondrosarcoma
Malignant Neoplasms
Mucopolysaccharidosis I
Tissue Damage

Pathways

Gastrulation
Notch Signaling Pathway
Gene Silencing
Stem Cell Differentiation
Cell Differentiation
Glycosylation
Bone Development
Pathogenesis

Embryonic Morphogenesis
Rna Interference
Localization

PTMs

Glycosylation

Research Areas

Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EXTL2

References

PMID: 9450183 by Wuyts W., et al. Identification and characterization of a novel member of the EXT gene family, EXTL2.

PMID: 9473480 by Saito T., et al. Structure, chromosomal location, and expression profile of EXTR1 and EXTR2, new members of the multiple exostoses gene family.