RNA-binding protein EWS Antibodies

AND EWSR1 ELISA kits, RNA-binding protein EWS Proteins

Many biological assays use antibodies to detect RNA-binding protein EWS, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RNA-binding protein EWS in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RNA-binding protein EWS antibodies...

We validate the specificity of these antibodies to RNA-binding protein EWS by testing them on tissues known to express EWSR1 positively and negatively. Browse below to find the EWSR1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: CCN2 Next: EXT1

EWSR1 Infographic by Boster Bio

All EWSR1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-EWSR1 Antibody Picoband®

5 Q&As

Human, Mouse, Rat

Flow Cytometry, IF, IHC, IHC-F, ICC, WB

$370
Cat # PB9585
100 μg/vial

Anti-EWSR1 Antibody Picoband® (monoclonal, 4B4)

Human, Monkey, Mouse

IHC, WB

$370
Cat # M00589
100 μg/vial

Anti-EWSR1 Mouse Monoclonal Antibody [Clone ID: OTI3F6]

+10

Human

IF, IHC, WB

$523
Cat # M00589-1
100 µl

Anti-EWSR1 Rabbit Monoclonal Antibody

Human, Mouse, Rat

IF, IHC, ICC, WB

$370
Cat # M00589-2
100 μl/vial

EWSR1 Overview

Facts about RNA-binding protein EWS.

EWSR1 3D structure. Source: alphafold

RNA-binding protein EWS (EWSR1)

Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) can play a role in the tumorigenic process.

They may disturb gene expression by imitating, or interfering with the normal use of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Gene Information

Human
Gene Name:	EWSR1
Uniprot:	Q01844
Entrez:	2130

Family

Belongs to:

RRM TET family

Alternative Names

bK984G1.4; Ewing sarcoma breakpoint region 1 protein; Ewing sarcoma breakpoint region 1; Ewings sarcoma EWS-Fli1 (type 1) oncogene; EWS oncogene; EWSRNA-binding protein EWS

Molecular Weight

Mass (kDA):
68.478 kDA

Genomic Context


Human

Location:	22q12.2
Sequence:	22; NC_000022.11 (29268254..29300523)

Tissue Specificity

Ubiquitous.

Subcellular Localizations

Nucleus. Cytoplasm. Cell membrane. Relocates from cytoplasm to ribosomes upon PTK2B/FAK2 activation.

Diseases

Neoplasms
Sarcoma
Ewings Sarcoma-primitive Neuroectodermal Tumor (pnet)
Chromosomal Translocation
Soft Tissue Neoplasms
Malignant Paraganglionic Neoplasm
Neuroectodermal Tumors
Sarcoma, Clear Cell
Bone Neoplasms
Feline Urological Syndrome
Malignant Neoplasms
Neuroectodermal Tumor, Primitive

Neoplasm Metastasis
Carcinoma
Chondrosarcoma
Histiocytoma
Histiocytoma, Benign Fibrous
Cell Transformation, Neoplastic
Extraskeletal Myxoid Chondrosarcoma

Interacting Proteins

ATPAF2
EP300
FUS
KAT5
MAPK1IP1L

PEF1
PLSCR1
PRMT1
PRR13
SEC24A

SEC24D
SSBP3
TFG
TRAF1
TRAF2

ZNF165

Pathways

Localization
Interphase
Oncogenesis
Pathogenesis
Reverse Transcription
Cell Differentiation
Metaphase
Rna Processing
Transport
Pigmentation
Cell Cycle
Cell Migration
Gene Silencing

Cellular Homeostasis
Brain Development
Immune Response
Dna Recombination
Regulation Of Gene Expression
Spermatogenesis
Cell Cycle Arrest

PTMs

Phosphorylation

Methylation

Deacetylation

Research Areas

Cancer
Cellular Markers
Neuroscience
Tumor Suppressors

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EWSR1

References

PMID: 1522903 by Delattre O., et al. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours.

PMID: 8307570 by Plougastel B., et al. Genomic structure of the EWS gene and its relationship to EWSR1, a site of tumor-associated chromosome translocation.