RNA-binding protein EWS Antibodies

RNA-binding protein EWS (EWSR1)

Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) can play a role in the tumorigenic process.

They may disturb gene expression by imitating, or interfering with the normal use of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Gene Information

Human
Gene Name:	EWSR1
Uniprot:	Q01844
Entrez:	2130

Family

Belongs to:
RRM TET family

Alternative Names

bK984G1.4; Ewing sarcoma breakpoint region 1 protein; Ewing sarcoma breakpoint region 1; Ewings sarcoma EWS-Fli1 (type 1) oncogene; EWS oncogene; EWSRNA-binding protein EWS

Molecular Weight

Mass (kDA):
68.478 kDA

Genomic Context

Human
Location:	22q12.2
Sequence:	22; NC_000022.11 (29268254..29300523)

Tissue Specificity

Ubiquitous.

Subcellular Localizations

Nucleus. Cytoplasm. Cell membrane. Relocates from cytoplasm to ribosomes upon PTK2B/FAK2 activation.

Diseases

• Neoplasms
• Sarcoma
• Ewings Sarcoma-primitive Neuroectodermal Tumor (pnet)
• Chromosomal Translocation
• Soft Tissue Neoplasms
• Malignant Paraganglionic Neoplasm
• Neuroectodermal Tumors
• Sarcoma, Clear Cell
• Bone Neoplasms
• Feline Urological Syndrome
• Malignant Neoplasms
• Neuroectodermal Tumor, Primitive

• Neoplasm Metastasis
• Carcinoma
• Chondrosarcoma
• Histiocytoma
• Histiocytoma, Benign Fibrous
• Cell Transformation, Neoplastic
• Extraskeletal Myxoid Chondrosarcoma

Interacting Proteins

• ATPAF2
• EP300
• FUS
• KAT5
• MAPK1IP1L

• PEF1
• PLSCR1
• PRMT1
• PRR13
• SEC24A

• SEC24D
• SSBP3
• TFG
• TRAF1
• TRAF2

• ZNF165

Pathways

• Localization
• Interphase
• Oncogenesis
• Pathogenesis
• Reverse Transcription
• Cell Differentiation
• Metaphase
• Rna Processing
• Transport
• Pigmentation
• Cell Cycle
• Cell Migration
• Gene Silencing

• Cellular Homeostasis
• Brain Development
• Immune Response
• Dna Recombination
• Regulation Of Gene Expression
• Spermatogenesis
• Cell Cycle Arrest

PTMs

• Phosphorylation

• Methylation

• Deacetylation

Research Areas

• Cancer
• Cellular Markers
• Neuroscience
• Tumor Suppressors

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EWSR1

Boster Bio - Best Uses Of The EWSR1 Marker

This article focuses on the Boster Bio and its best uses in the research community. This article discusses the reasons why DS studies are beneficial to create additional independent marker panels. It also describes how these methods are focused more on relative expression ratios than absolute expression strength. Boster Bio's research primary as well as second antibodies are also discussed in this article. These antibodies are trusted by researchers due to their high-qualityand reliable results.

Researchers believe in Boster Bio's main and second antibody for research.

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Boster Bio's reagents have been extensively employed in research and are well-known for their excellent quality and affordability. Our antibodies are derived from human sera. They have been approved by the National Institutes of Health as and other reliable sources. The quality of these antibodies is unrivaled and is backed by our 30 day quality guarantee. Many researchers around the world use our primary and secondary research antibodies. They include ANTI MOUSE/HUMAN GALECTIN-3 antibody, MAC-2 antibody, and mouse anti–p62 fusion protein.