Limbin Antibodies

AND Evc2 ELISA kits, Limbin Proteins

Many biological assays use antibodies to detect Limbin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Limbin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Limbin antibodies...

We validate the specificity of these antibodies to Limbin by testing them on tissues known to express Evc2 positively and negatively. Browse below to find the Evc2 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Evc2 Infographic by Boster Bio

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Evc2 Overview

Facts about Limbin.

Limbin (Evc2)

Part of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling (PubMed:21356043, PubMed:24582806). Plays a crucial role in bone formation and skeletal growth (PubMed:21356043).

May be involved in early embryonic morphogenesis (PubMed:21356043). .

Gene Information

Mouse
Gene Name:	Evc2
Uniprot:	Q8K1G2
Entrez:	68525

Family

Belongs to:

No superfamily

Alternative Names

Ellis van Creveld syndrome 2; EVC2; LBN; LBNlimbin; Limbin; WAD

Molecular Weight

Mass (kDA):
137.639 kDA

Genomic Context


Mouse

Location:	5\|5 B3
Sequence:	5;

Tissue Specificity

Expressed in long and cranial bones, kidney and heart. Strongly expressed in proliferating chondrocytes, osteoblasts and osteoclasts.

Diseases

Ellis-van Creveld Syndrome
Dysplasia
Polydactyly
Dwarfism
Dysostoses
Tooth Abnormalities
Skeletal Dysplasia
Congenital Heart Defects
Curry-hall Syndrome
Ectodermal Dysplasia
Fetal Diseases
Dystrophy

Heart Diseases
Congenital Heart Disease
Endocardial Cushion Defects
Limb Deformities, Congenital
Dystrophia Unguium
Congenital Abnormality

Pathways

Localization
Pathogenesis
Transport
Transposition
Signal Transmission
Bone Development
Intraflagellar Transport
Odontogenesis

Heart Development
Tissue Homeostasis

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Evc2

References

PMID: 12136126 by Takeda H., et al. Positional cloning of the gene LIMBIN responsible for bovine chondrodysplastic dwarfism.

PMID: 21356043 by Blair H.J., et al. Evc2 is a positive modulator of Hedgehog signalling that interacts with Evc at the cilia membrane and is also found in the nucleus.