ETHE1 Antibodies

AND ETHE1 ELISA kits, ETHE1 Proteins

Many biological assays use antibodies to detect ETHE1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ETHE1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ETHE1 antibodies...

We validate the specificity of these antibodies to ETHE1 by testing them on tissues known to express ETHE1 positively and negatively. Browse below to find the ETHE1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ETHE1 Infographic by Boster Bio

All ETHE1 Products

Product

Figures

Specificity

Applications

Price

Anti-ETHE1 Antibody

Human, Mouse, Rat

IF, IHC, ICC, WB

$405
Cat # A05557
100ul

Human ETHE1 Recombinant Protein

SDS-PAGE

$265
Cat # PROTO95571
Starting from 20ug

ETHE1 (NM_014297) Human Over-expression Lysate

Human

$628
Cat # LS023474
100 µg

ETHE1 Overview

Facts about Persulfide dioxygenase ETHE1, mitochondrial.

ETHE1 3D structure. Source: alphafold

Persulfide dioxygenase ETHE1, mitochondrial (ETHE1)

Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues.

ETHE1 absorbs molecular oxygen to catalyze the oxidation of the persulfide, once it's been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, because of the inhibition of cytochrome c oxidase.

Gene Information

Human
Gene Name:	ETHE1
Uniprot:	O95571
Entrez:	23474

Family

Belongs to:

metallo-beta-lactamase superfamily

Alternative Names

D83198; EC 3.1.2.6; ethylmalonic encephalopathy 1; Ethylmalonic encephalopathy protein 1; Hepatoma subtracted clone one protein; HSCOEC 3.-; protein ETHE1, mitochondrial; YF13H12

Molecular Weight

Mass (kDA):
27.873 kDA

Genomic Context


Human

Location:	19q13.31
Sequence:	19; NC_000019.10 (43506719..43527201, complement)

Tissue Specificity

Ubiquitously expressed.

Subcellular Localizations

Cytoplasm. Nucleus. Mitochondrion matrix.

Diseases

Ethylmalonic Encephalopathy
Encephalopathies
Brain Diseases, Metabolic, Inborn
Metabolic Diseases
Petechiae
Diarrhea
Chronic Diarrhea
Inborn Errors Of Metabolism
Brain Diseases
Deficiency Of Butyryl-coa Dehydrogenase
Purpura

Muscle Hypotonia
Malignant Neoplasms
Cytochrome-c Oxidase Deficiency
Liver Carcinoma
Diabetes Mellitus

Pathways

Excretion
Aging
Fatty Acid Oxidation
Transport
Transsulfuration
Sulfur Oxidation
Ion Transport
Oxidative Phosphorylation
Insemination
Localization
Embryo Development

Inflammatory Response
Cellularization
Cell Death
Endosperm Development
Hemostasis
Glycolysis

PTMs

Oxidation

Deacetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ETHE1

References

PMID: 12398897 by Higashitsuji H., et al. A novel protein overexpressed in hepatoma accelerates export of NF- kappa B from the nucleus and inhibits p53-dependent apoptosis.

PMID: 14732903 by Tiranti V., et al. Ethylmalonic encephalopathy is caused by mutations in ETHE1, a gene encoding a mitochondrial matrix protein.