Extended synaptotagmin-1 Antibodies

AND ESYT1 ELISA kits, Extended synaptotagmin-1 Proteins

Many biological assays use antibodies to detect Extended synaptotagmin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Extended synaptotagmin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Extended synaptotagmin-1 antibodies...

We validate the specificity of these antibodies to Extended synaptotagmin-1 by testing them on tissues known to express ESYT1 positively and negatively. Browse below to find the ESYT1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ESYT1 Infographic by Boster Bio

All ESYT1 Products

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Product

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Specificity

Applications

Price

Anti-Extended synaptotagmin-1 ESYT1 Antibody

Human, Mouse, Rat

IF, ICC, WB

$405
Cat # A07673
100ul

FAM62A (ESYT1) (NM_015292) Human Recombinant Protein

$1062
Cat # PROTQ9BSJ8
20 µg

FAM62A (ESYT1) (NM_015292) Human Over-expression Lysate

Human

$628
Cat # LS023344
100 µg

ESYT1 Overview

Facts about Extended synaptotagmin-1.

ESYT1 3D structure. Source: alphafold

Extended synaptotagmin-1 (ESYT1)

Binds glycerophospholipids in a barrel-like domain and might play a role in cellular lipid transport (By similarity). Binds calcium (through the C2 domain ) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels.

Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. .

Gene Information

Human
Gene Name:	ESYT1
Uniprot:	Q9BSJ8
Entrez:	23344

Family

Belongs to:

extended synaptotagmin family

Alternative Names

E-Syt1; extended synaptotagmin-like protein 1; family with sequence similarity 62 (C2 domain containing), member A; KIAA0747FAM62A; MBC2extended synaptotagmin-1; Membrane-bound C2 domain-containing protein

Molecular Weight

Mass (kDA):
122.856 kDA

Genomic Context


Human

Location:	12q13.2
Sequence:	12; NC_000012.12 (56128202..56144676)

Tissue Specificity

Widely expressed.

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Peripheral membrane protein. Localizes primarily to the endoplasmic reticulum. Recruited to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels.

Interacting Proteins

ESYT2
ESYT3

PTMs

Acetylation

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ESYT1

References

PMID: 17360437 by Min S.-W., et al. E-Syts, a family of membranous Ca2+-sensor proteins with multiple C2 domains.

PMID: 23791178 by Giordano F., et al. PI(4,5)P(2)-dependent and Ca(2+)-regulated ER-PM interactions mediated by the extended synaptotagmins.