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- Table of Contents
Facts about ERO1-like protein alpha.
Following P4HB reoxidation, passes its electrons to molecular oxygen through FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the correct folding of immunoglobulins.
Human | |
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Gene Name: | ERO1A |
Uniprot: | Q96HE7 |
Entrez: | 30001 |
Belongs to: |
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EROs family |
EC 1.8.4; EC 1.8.4.-; Endoplasmic oxidoreductin-1-like protein; ERO1 (S. cerevisiae)-like; ERO1A; ERO1-alpha; ERO1L alpha; ERO1-l alpha; ERO1L; ERO1-L; ERO1-L-alpha; ERO1-like (S. cerevisiae); ERO1-like alpha; ERO1-like protein alpha; ERO1-like; oxidoreductin-1-L-alpha
Mass (kDA):
54.393 kDA
Human | |
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Location: | 14q22.1 |
Sequence: | 14; NC_000014.9 (52639915..52695750, complement) |
Widely expressed at low level. Expressed at high level in upper digestive tract. Highly expressed in esophagus. Weakly expressed in stomach and duodenum.
Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. The association with ERP44 is essential for its retention in the endoplasmic reticulum.
PMID: 10671517 by Cabibbo A., et al. ERO1-L, a human protein that favors disulfide bond formation in the endoplasmic reticulum.
PMID: 11707280 by Pagani M., et al. The C-terminal domain of yeast Ero1p mediates membrane localization and is essential for function.