ERO1-like protein alpha (ERO1A)

Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, to be able to permit P4HB to sustain additional rounds of disulfide formation.

Following P4HB reoxidation, passes its electrons to molecular oxygen through FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the correct folding of immunoglobulins.