ERN2 Antibodies

Serine/threonine-protein kinase/endoribonuclease IRE2 (ERN2)

Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic.

Appears to play no part in the unfolded-protein reply, unlike closely related proteins. .

Gene Information

Human
Gene Name:	ERN2
Uniprot:	Q76MJ5
Entrez:	10595

Family

Belongs to:
protein kinase superfamily

Alternative Names

EC 2.7.11; endoplasmic reticulum to nucleus signaling 2; endoplasmic reticulum to nucleus signalling 2; Endoplasmic reticulum-to-nucleus signaling 2; ER to nucleus signalling 2; hIRE2p; inositol-requiring 1 beta; Inositol-requiring protein 2; IRE1, S. cerevisiae, homolog of; Ire1-beta; IRE1bIRE1 beta; IRE2; serine/threonine-protein kinase/endoribonuclease IRE2

Molecular Weight

Mass (kDA):
102.48 kDA

Genomic Context

Human
Location:	16p12.2
Sequence:	16; NC_000016.10 (23690310..23713248, complement)

Subcellular Localizations

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Diseases

• Endoplasmic Reticulum Stress
• Physiological Stress
• Malignant Neoplasms
• Neoplasms
• Diabetes Mellitus
• Alzheimer's Disease
• Ischemia
• Inflammation
• Neurodegenerative Disorders
• Hypoxia
• Diabetes Mellitus, Non-insulin-dependent
• Parkinson Disease

• Obesity
• Virus Diseases
• Insulin Resistance
• Tumor Angiogenesis
• Hepatitis
• Neuroblastoma
• Atherosclerosis

Pathways

• Cell Death
• Translation
• Protein Folding
• Secretion
• Pathogenesis
• Secretory Pathway
• Proteolysis
• Autophagy
• Cell Differentiation
• Response To Endoplasmic Reticulum Stress
• Response To Stress
• Cell Cycle
• Angiogenesis

• Plasma Cell Differentiation
• Programmed Cell Death
• Mrna Splicing
• Transport
• Protein Secretion
• Inflammatory Response
• Induction Of Apoptosis

PTMs

• Phosphorylation
• Cleavage
• Dephosphorylation

• Ubiquitination
• Glycosylation
• Acetylation

• Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ERN2

Best Uses Of The ERN2 Marker From Boster Bio

If you are interested in using the ERN2 marker, you have come to the right place. In this article, we will discuss the Boster Bio ERN2 marker and the Anti-ERN2 marker. We will also discuss the research applications of these products. These products are applicable to scientists worldwide. These markers are used to examine a variety of biological processes, including the development of new drugs and medicines.

Boster Bio

The ERN2 marker is a protein in the genome that induces translational repression through the 28S ribosomal RNA cleavage pathway. In response to ER stress, it induces translational repression, although it does not appear to be involved in the unfolded-protein response. However, overexpression of ERN2 in mammalian cells activates BiP expression, leading to programmed cell death. The proteins in ERN2 are implicated in various aspects of the ER stress response in mammalian cells, including the activation of BiP and its function in promoting programmed cell death.

ERN2

ERN2 is a member of the ER stress response and induces translational repression in response to ER stress. It does not appear to participate in the unfolded protein response (UPR) and is also implicated in a range of facets of the ER stress response in mammalian cells. ERN2 is a multifunctional protein that is able to respond to multiple ER stress mechanisms, including ER-associated stress. Boster Bio's antibodies are validated in multiple methods and on known positive and negative samples.

Anti-ERN2 Marker

The Anti-ERN2 Marker in Boster's catalog (A05659-2) reacts with Human. It can be stored at -20 degC for one year, or at 4 degC for a month. This reagent is supplied with 0.2 mg of Na2HPO4 and 4 mg of trehalose. The Boster antibody recognizes human recombinant protein. If the Anti-ERN2 antibody fails to detect human recombinant protein, a blocking peptide must be purchased to block the reaction.

IRE1b evolved in response to the host-environment interface. In the mucosal region, barrier epithelial cells are exposed to a host's immune response by generating extracellular mucus. In the mucosa, dedicated molecules regulate mucosal homeostasis, and IRE1b plays an essential role in maintaining the balance of mucosal homeostasis.

Research applications

The ERN2 marker has several biological applications. For example, it can be used to monitor cellular protein degradation in the ER. Its expression increases when cells are exposed to ER stress. In the ER, autophagy is a crucial pathway that controls protein degradation. It is induced when the number of misfolded proteins increases. These misfolded proteins are eventually degraded by the lysosome and are removed from the cytoplasm.

The ER is an organelle that functions in many aspects of cellular metabolism. It contributes to calcium and lipid metabolism, and is involved in secretory protein synthesis. It also serves as a quality-control center, ensuring that folded proteins reach their intended site of action. Studies have shown that up to 30% of all proteins are cotranslationally targeted to the ER, where foldases and chaperones perform their functions. The ER is responsible for a variety of processes, including cleavage of signal sequences, N-linked glycosylation, lipid conjugation, and protein folding.

The ERN2 marker has a wide range of applications, including the investigation of cancer metastasis. The markers are useful for determining the presence of cancer cells, as well as to monitor the activity of tumor-associated genes. Several studies have shown that ERN2 expression increases with the severity of ER stress. In contrast, IRE1b selectively induces translational repression through 28S ribosomal RNA cleavage.

The ER also plays a critical role in Ca2+ homeostasis. It forms several physical contacts with mitochondria and the plasma membrane. These contacts are regulated by the protein kinase RNA-activated ER kinase. The SEC22b and the VEAS-7 are involved in maintaining the ER-PM interaction and PM expansion. In addition, the ER is a key part of the cell's response to stress.

Steven Boster

Steve Boster was born and raised in San Angelo, Texas. He practiced emergency medicine for 33 years before settling down to paint full-time. Boster's studio is located in the Chicken Farm Art Center in San Angelo. His work consists of realistic paintings with a slant towards early impressionism. Boster used vivid colors to portray the animals that he loved. Boster was an avid hunter and outdoorsman his entire life. When selling his paintings, Boster donates a portion of the sale price to the Fisher House Foundation, a charity that provides free meals for hospitalized veterans.