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ERN1 Antibodies
AND ERN1 ELISA kits, ERN1 Proteins
Many biological assays use antibodies to detect ERN1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ERN1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ERN1 antibodies...
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ERN1 Infographic by Boster Bio
All ERN1 Products
Product
Figures
Specificity
Applications
Price
Anti-IRE1/ERN1 Antibody Picoband®
3 Citations 7 Q&As
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A00683-1
100 μg/vial
Cat # A00683-1
100 μg/vial
Anti-IRE1p ERN1 Antibody
1 Citations
Human, Mouse, Rat
ELISA, IF, IHC-P, ICC, WB
$449
Cat # A00683
0.1 mg
Cat # A00683
0.1 mg
ERN1 Overview
Facts about Serine/threonine-protein kinase/endoribonuclease IRE1.
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)
Serine/threonine-protein kinase and endoribonuclease that functions as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11779464, PubMed:11175748, PubMed:12637535, PubMed:9637683, PubMed:21317875). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP (PubMed:21317875).
Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain name to homodimerize, boosting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity (PubMed:21317875). The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA (PubMed:11779464, PubMed:24508390, PubMed:21317875).
Gene Information
| Human | |
|---|---|
| Gene Name: | ERN1 |
| Uniprot: | O75460 |
| Entrez: | 2081 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11; endoplasmic reticulum to nucleus signaling 1; Endoplasmic reticulum-to-nucleus signaling 1; ER to nucleus signalling 1; FLJ30999; hIRE1p; inositol-requiring 1; Inositol-requiring protein 1; IRE 1a; ire1 alpha p Ser724; ire1 alpha phosphorylation; IRE1a; ire1-alpha; IRE1MGC163279; IRE1P; MGC163277; phospho ire1 alpha; phospho-ire1 alpha; phospho-ire1a; p-ire1 alpha; protein kinase/endoribonuclease; serine/threonine-protein kinase/endoribonuclease IRE1
Molecular Weight
Mass (kDA):
109.735 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q23.3 |
| Sequence: | 17; NC_000017.11 (64039142..64132469, complement) |
Tissue Specificity
Ubiquitously expressed. High levels observed in pancreatic tissue.
Subcellular Localizations
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Diseases
- Endoplasmic Reticulum Stress
- Physiological Stress
- Diabetes Mellitus
- Malignant Neoplasms
- Insulin Resistance
- Inflammation
- Obesity
- Neoplasms
- Nerve Degeneration
- Diabetes Mellitus, Non-insulin-dependent
- Hyperglycemia
- Insulin Sensitivity
Interacting Proteins
- Bak1
- BAX
- Bax
- HSPA1A
- HSPA5
- Hspa5
- OS9
- SEL1L
- SYVN1
- TAOK3
Pathways
- Cell Death
- Pathogenesis
- Secretion
- Autophagy
- Translation
- Protein Folding
- Mrna Splicing
- Cell Proliferation
- Cell Cycle
- Localization
- Nodulation
- Insulin Secretion
- Intracellular Signal Transduction
PTMs
- Phosphorylation
- Cleavage
Research Areas
- Apoptosis
- Cell Biology
- Diabetes Research
- Hypoxia
- Lipid and Metabolism
- Neuroscience
- Phospho-Specific
- Signal Transduction
- Unfolded Protein Response
- Unfolded Protein Response (UPR)
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ERN1
bosterbio.com/bosterbio-gene-info-cards/ERN1
References
PMID: 9637683 by Tirasophon W., et al. A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells.
PMID: 11779464 by Yoshida H., et al. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor.
4 Publications of Boster ERN1 Antibodies & ELISA Kits
- PubMed ID: 10.3892/ol.2013.1651, Endoplasmic reticulum stress in diethylnitrosamine‑induced rat liver cancer
- PubMed ID: 10.1038/s41419-020-02930-y, BCAT1 binds the RNA-binding protein ZNF423 to activate autophagy via the IRE1-XB...
- PubMed ID: 10.1007/s12031-016-0755-2, Role of the Endoplasmic Reticulum Pathway in the Medial Prefrontal Cortex in Pos...
- PubMed ID: 32552877, Chen KY,Chen YJ,Cheng CJ,Jhan KY,Wang LC.Excretory/secretory products of Angiost...
*More publications can be found for each product on its corresponding product page