Erlin-2 Antibodies

AND ERLIN2 ELISA kits, Erlin-2 Proteins

Many biological assays use antibodies to detect Erlin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Erlin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Erlin-2 antibodies...

We validate the specificity of these antibodies to Erlin-2 by testing them on tissues known to express ERLIN2 positively and negatively. Browse below to find the ERLIN2 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: SEPTIN9 Next: ERG28

ERLIN2 Infographic by Boster Bio

All ERLIN2 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Human ERLIN2 Recombinant Protein

SDS-PAGE, Denatured

$250
Cat # PROTO94905
Starting from 20ug

Anti-Erlin-2/ERLIN2 Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A07042-2
100 μg/vial

Anti-Erlin-2 Rabbit Monoclonal Antibody

Human, Mouse

IF, IHC, ICC, WB

$370
Cat # M07042
100 μl/vial

Anti-Erlin-2/ERLIN2 Antibody Picoband® (monoclonal, 3H9A2)

Human

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # M07042-1
100 μg/vial

SPFH2 (ERLIN2) (NM_007175) Human Over-expression Lysate

Human

$628
Cat # LS011160
100 µg

ERLIN2 Overview

Facts about Erlin-2.

ERLIN2 3D structure. Source: alphafold

Erlin-2 (ERLIN2)

Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 (PubMed:19240031, PubMed:17502376). Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex (PubMed:21343306).

Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complicated (PubMed:24217618).

Gene Information

Human
Gene Name:	ERLIN2
Uniprot:	O94905
Entrez:	11160

Family

Belongs to:

band 7/mec-2 family

Alternative Names

C8orf2SPFH domain-containing protein 2; Endoplasmic reticulum lipid raft-associated protein 2; ER lipid raft associated 2; Erlin-2; MGC87072; NET32; SPFH domain family, member 2; SPFH2chromosome 8 open reading frame 2; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2

Molecular Weight

Mass (kDA):
37.84 kDA

Genomic Context


Human

Location:	8p11.23
Sequence:	8; NC_000008.11 (37736627..37758422)

Tissue Specificity

Ubiquitous.

Subcellular Localizations

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Associated with lipid raft-like domains of the endoplasmic reticulum membrane.

Diseases

Malignant Neoplasms
Malignant Neoplasm Of Breast
Spastic Paraplegia, Hereditary
Paraplegia
Muscle Spasticity
Cell Transformation, Neoplastic
Spastic Paraplegia
Neurodegenerative Disorders
Weakness
Motor Neuron Disease
Mammary Neoplasms
Nerve Degeneration

Optic Atrophy
Carcinoma, Transitional Cell
Sclerosis
Primary Lateral Sclerosis
Polyneuropathy
Dementia

Interacting Proteins

AMFR
ERLIN1
TMUB1

Pathways

Rna Interference
Cell Growth
Localization
Transport
Cell Proliferation
Cell Death
Protein Maturation
Lipid Storage
Regulation Of Gene Expression

Transcytosis
Cholesterol Homeostasis
Oncogenesis

PTMs

Ubiquitination

Biotinylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ERLIN2

References

PMID: 10449903 by Ikegawa S., et al. Cloning and characterization of a novel gene (C8orf2), a human representative of a novel gene family with homology to C. elegans C42.C1.9.

PMID: 19240031 by Pearce M.M.P., et al. An endoplasmic reticulum (ER) membrane complex composed of SPFH1 and SPFH2 mediates the ER-associated degradation of inositol 1,4,5- trisphosphate receptors.