3'-5' exoribonuclease 1 Antibodies

AND Eri1 ELISA kits, 3'-5' exoribonuclease 1 Proteins

Many biological assays use antibodies to detect 3'-5' exoribonuclease 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with 3'-5' exoribonuclease 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop 3'-5' exoribonuclease 1 antibodies...

We validate the specificity of these antibodies to 3'-5' exoribonuclease 1 by testing them on tissues known to express Eri1 positively and negatively. Browse below to find the Eri1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Eri1 Infographic by Boster Bio

All Eri1 Products

Product

Figures

Specificity

Applications

Price

Anti-ERI1/Hexo Antibody

4 Q&As

Human

$360
Cat # A07945
100 µl

Anti-3'-5' exoribonuclease 1 ERI1 Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A07945-1
100ul

Anti-HEXO (ERI1) Mouse Monoclonal Antibody [Clone ID: OTI1B3]

Human, Monkey, Rat

IHC, WB

$523
Cat # M07945
100 µl

HEXO (ERI1) (NM_153332) Human Over-expression Lysate

Human

$628
Cat # LS090459
100 µg

Eri1 Overview

Facts about 3'-5' exoribonuclease 1.

3'-5' exoribonuclease 1 (Eri1)

RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates.

Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, indicating a possible role as regulator of RNA interference (RNAi). Binds with high affinity to the 3' side of the stem-loop structure and to the downstream cleavage product (DCP) of histone pre-mRNAs.

Gene Information

Mouse
Gene Name:	Eri1
Uniprot:	Q7TMF2
Entrez:	67276

Family

Belongs to:

No superfamily

Alternative Names

3' exoribonuclease; 3'-5' exonuclease ERI1; 3'EXO; 3'HEXO; EC 3.1; enhanced RNAi three prime mRNA exonuclease homolog 1; Eri-1 homolog; exoribonuclease 1; HEXO; histone mRNA 3' end-specific exonuclease; Histone mRNA 3'-end-specific exoribonuclease; Histone mRNA 3'-exonuclease 1; MGC35395; Protein 3'hExo; THEX1; three prime histone mRNA exonuclease 1,3'-5' exoribonuclease 1; three prime mRNA exonuclease 1

Molecular Weight

Mass (kDA):
39.493 kDA

Genomic Context


Mouse

Location:	8\|8 A4
Sequence:	8;

Tissue Specificity

Widely expressed with high levels in spleen, thymus and testis (at protein level).

Diseases

Neoplasms
Sclerosis
Melanoma
Hepatitis
B16 Malignant Melanoma
Hepatitis B
Growth Retardation
Epilepsy
Melanoma, Experimental
Dysplasia
Cortical Dysplasia

Malignant Neoplasms
Cytomegalovirus Infections
Nervousness
Neuropathology Disease
Epilepsy, Temporal Lobe

Pathways

Rna Interference
Methylation
Rrna Processing
Histone H3-k9 Methylation
Heterochromatin Assembly
Cell Proliferation
Gene Silencing
Translation
S Phase

Negative Regulation Of Rna Interference
Regulation Of Rna Interference
Rna Processing

PTMs

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Eri1

References

PMID: 18438418 by Ansel K.M., et al. Mouse Eri1 interacts with the ribosome and catalyzes 5.8S rRNA processing.

PMID: 19470752 by Yang X.-C., et al. Three proteins of the U7-specific Sm ring function as the molecular ruler to determine the site of 3'-end processing in mammalian histone pre-mRNA.