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ERCC3 Antibodies
AND ERCC3 ELISA kits, ERCC3 Proteins
Many biological assays use antibodies to detect ERCC3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ERCC3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ERCC3 antibodies...
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ERCC3 Infographic by Boster Bio
All ERCC3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$523
Cat # M03103-1
100 µl
Cat # M03103-1
100 µl
ERCC3 Overview
Facts about General transcription and DNA repair factor IIH helicase subunit XPB.
General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3)
ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to enable the excision of the damaged oligonucleotide and its replacement by a new DNA fragment.
In transcription, TFIIH has an important role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.
Gene Information
| Human | |
|---|---|
| Gene Name: | ERCC3 |
| Uniprot: | P19447 |
| Entrez: | 2071 |
Family
| Belongs to: |
|---|
| helicase family |
Alternative Names
Basic transcription factor 2 89 kDa subunit; BTF2 p89; BTF2; DNA excision repair protein ERCC-3; DNA repair protein complementing XP-B cells; EC 3.6.1; EC 3.6.4.12; ERCC3; excision repair cross-complementing rodent repair deficiency, complementationgroup 3 (xeroderma pigmentosum group B complementing); GTF2H; RAD25; TFIIH basal transcription factor complex 89 kDa subunit; TFIIH basal transcription factor complex helicase XPB subunit; TFIIH p89; TFIIH; Xeroderma pigmentosum group B-complementing protein; xeroderma pigmentosum, complementation group B; XPB; XPBC; XPBTFIIH 89 kDa subunit
Molecular Weight
Mass (kDA):
89.278 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q14.3 |
| Sequence: | 2; NC_000002.12 (127257290..127294166, complement) |
Subcellular Localizations
Nucleus.
Diseases
- Xeroderma
- Xeroderma Pigmentosum
- Malignant Neoplasms
- Cockayne Syndrome
- Neoplasms
- Xeroderma Pigmentosum, Group B
- Carcinoma
- Malignant Neoplasm Of Skin
- Trichothiodystrophy Syndromes
- Adenocarcinoma
- Malignant Neoplasm Of Lung
- Ovarian Neoplasm
- Dna Repair Disorder
Interacting Proteins
- CEP70
- ERCC2
- GTF2H5
- KPNA3
- PSMC5
- Psmc5
- RAD23B
- XIAP
- XPC
Pathways
- Dna Repair
- Cell Cycle
- Pathogenesis
- Cell Death
- Reverse Transcription
- Localization
- Dna Replication
- Dna Excision
- Cell Growth
- Transport
- Induction Of Apoptosis
- Protein Phosphorylation
- Response To Gamma Radiation
PTMs
- Phosphorylation
- Cleavage
Research Areas
- Cancer
- DNA Repair
- Nucleotide Excision Repair
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ERCC3
bosterbio.com/bosterbio-gene-info-cards/ERCC3
References
PMID: 2111438 by Weeda G., et al. Molecular cloning and biological characterization of the human excision repair gene ERCC-3.
PMID: 2167179 by Weeda G., et al. A presumed DNA helicase encoded by ERCC-3 is involved in the human repair disorders Xeroderma pigmentosum and Cockayne's syndrome.