ERC1 Antibodies

AND ERC1 ELISA kits, ERC1 Proteins

Many biological assays use antibodies to detect ERC1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ERC1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ERC1 antibodies...

We validate the specificity of these antibodies to ERC1 by testing them on tissues known to express ERC1 positively and negatively. Browse below to find the ERC1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ERC1 Infographic by Boster Bio

All ERC1 Products

Product

Figures

Specificity

Applications

Price

Anti-ERC1 Antibody

Human, Mouse, Rat

$405
Cat # A05640
100ul

ERC1 (NM_178040) Human Over-expression Lysate

Human

$960
Cat # LS023085
100 µg

ERC1 Overview

Facts about ELKS/Rab6-interacting/CAST family member 1.

ERC1 3D structure. Source: alphafold

ELKS/Rab6-interacting/CAST family member 1 (ERC1)

Regulatory subunit of the IKK complex.
Probably recruits IkappaBalpha/NFKBIA to the complex.

May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which modulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ.

Gene Information

Human
Gene Name:	ERC1
Uniprot:	Q8IUD2
Entrez:	23085

Family

Belongs to:

No superfamily

Alternative Names

ELKS/RAB6-interacting/CAST family member 1; ELKSCAST2; ERC-1; FLJ31750; KIAA1081Cast2; MGC12974; RAB6 interacting protein 2; Rab6-interacting protein 2; RAB6IP2

Molecular Weight

Mass (kDA):
128.086 kDA

Genomic Context


Human

Location:	12p13.33
Sequence:	12; NC_000012.12 (990030..1495933)

Tissue Specificity

Widely expressed. Isoform 2 and isoform 4 are abundantly expressed in brain. Isoform 1 and isoform 3 are predominantly expressed in testis and thyroid, and isoform 1 predominates in other tissues tested.

Subcellular Localizations

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Cell junction, synapse, presynaptic cell membrane. Recruited on Golgi membranes by RAB6A in a GTP-dependent manner (By similarity).

Diseases

Malignant Neoplasms
Genotoxic Stress
Myeloid Neoplasm
Epilepsy, Generalized
Ataxia
Carcinoma, Papillary
Carcinoma
Glomerulonephritis
Nephrosclerosis
Speech Delay
Neoplasms
Lupus Erythematosus, Systemic
Chromosome Breakage

Papillary Thyroid Carcinoma
Febrile Convulsions
Dysequilibrium Syndrome
Apraxias
Apraxic Aphonia
Iga Glomerulonephritis
Hepatitis

Interacting Proteins

Cacnb4

Pathways

Transport
Exocytosis
Secretion
Intracellular Transport
Cell Proliferation
Neurotransmitter Transport
Microtubule-based Transport
Localization
Nuclear Export
Cytokinesis

Flight
Coagulation
Pathogenesis
Rna Interference

PTMs

Phosphorylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ERC1

References

PMID: 10337992 by Nakata T., et al. Fusion of a novel gene, ELKS, to RET due to translocation t(10;12)(q11;p13) in a papillary thyroid carcinoma.

PMID: 12203787 by Nakata T., et al. Differential expression of multiple isoforms of the ELKS mRNAs involved in a papillary thyroid carcinoma.