This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
ERBB4 Antibodies
AND ERBB4 ELISA kits, ERBB4 Proteins
Many biological assays use antibodies to detect ERBB4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ERBB4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ERBB4 antibodies...
Previous: CCN2
Next: ERCC4
ERBB4 Infographic by Boster Bio
All ERBB4 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, IF, ICC, WB
$370
Cat # M00296
100 μl
Cat # M00296
100 μl
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A00296Y1284-1
100ul
Cat # A00296Y1284-1
100ul
Human, Mouse, Rat
IHC, WB
$523
Cat # M00296-2
100 µl
Cat # M00296-2
100 µl
ERBB4 Overview
Facts about Receptor tyrosine-protein kinase erbB-4.
Receptor tyrosine-protein kinase erbB-4 (ERBB4)
Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the adrenal gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation.
Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation.
Gene Information
| Human | |
|---|---|
| Gene Name: | ERBB4 |
| Uniprot: | Q15303 |
| Entrez: | 2066 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4; EC 2.7.10; EC 2.7.10.1; ErbB4; HER4; HER4MGC138404; p180erbB4; Proto-oncogene-like protein c-ErbB-4; receptor tyrosine-protein kinase erbB-4; Tyrosine kinase-type cell surface receptor HER4; v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4; v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
Molecular Weight
Mass (kDA):
146.808 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q34 |
| Sequence: | 2; NC_000002.12 (211375717..212538802, complement) |
Tissue Specificity
Expressed at highest levels in brain, heart, kidney, in addition to skeletal muscle, parathyroid, cerebellum, pituitary, spleen, testis and breast. Lower levels in thymus, lung, salivary gland, and pancreas. Isoform JM-A CYT-1 and isoform JM-B CYT-1 are expressed in cerebellum, but only the isoform JM-B is expressed in the heart.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. In response to NRG1 treatment, the activated receptor is internalized.; [ERBB4 intracellular domain]: Nucleus. Mitochondrion. Following proteolytical processing E4ICD (E4ICD1 or E4ICD2 generated from the respective isoforms) is translocated to the nucleus. Significantly more E4ICD2 than E4ICD1 is found in the nucleus. E4ICD2 colocalizes with YAP1 in the nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Schizophrenia
- Mammary Neoplasms
- Carcinoma
- Nervousness
- Malignant Paraganglionic Neoplasm
- Cell Transformation, Neoplastic
- Tissue Adhesions
- Neoplasm Metastasis
- Carcinogenesis
- Malignant Neoplasm Of Lung
Interacting Proteins
- ABL2
- BYSL
- DLG4
- EGFR
- ERBB2
- ERBB3
- HSP90AB1
- SHC1
- TROAP
- YAP1
Pathways
- Cell Proliferation
- Localization
- Cell Growth
- Pathogenesis
- Angiogenesis
- Cell Migration
- Regeneration
- Cell Cycle
- Secretion
- Myelination
- Cell Death
- Cell Adhesion
- Proteolysis
PTMs
- Phosphorylation
- Cleavage
- Ubiquitination
- Dephosphorylation
- Methylation
- Hydroxylation
- Palmitoylation
Research Areas
- Angiogenesis
- Cancer
- Protein Kinase
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ERBB4
bosterbio.com/bosterbio-gene-info-cards/ERBB4
References
PMID: 8383326 by Plowman G.D., et al. Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family.
PMID: 9334263 by Elenius K., et al. A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester.