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- Table of Contents
Facts about Epidermal growth factor receptor substrate 15.
Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs).
Human | |
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Gene Name: | EPS15 |
Uniprot: | P42566 |
Entrez: | 2060 |
Belongs to: |
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No superfamily |
AF1P; AF-1P; ALL1 fused gene from chromosome 1; epidermal growth factor receptor pathway substrate 15; epidermal growth factor receptor substrate 15; Eps15; MLLT5; Protein AF-1p; Protein Eps15
Mass (kDA):
98.656 kDA
Human | |
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Location: | 1p32.3 |
Sequence: | 1; NC_000001.11 (51354263..51519275, complement) |
Ubiquitously expressed.
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Recruited to the plasma membrane upon EGFR activation and localizes to coated pits. Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments and in cytoplasmic juxtanuclear structures called aggresomes.; [Isoform 2]: Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Colocalizes with HGS on bilayered clathrin coats on endosomes.
PMID: 8183552 by Wong W.T., et al. The human eps15 gene, encoding a tyrosine kinase substrate, is conserved in evolution and maps to 1p31-p32.
PMID: 8134107 by Bernard O.A., et al. A novel gene, AF-1p, fused to HRX in t(1;11)(p32;q23), is not related to AF-4, AF-9 nor ENL.