Ephrin type-B receptor 1 Antibodies

Ephrin type-B receptor 1 (EPHB1)

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands living on adjacent cells, resulting in contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is known as forward signaling while the signaling pathway downstream of the ephrin ligand is known as reverse signaling.

Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline.

Gene Information

Human
Gene Name:	EPHB1
Uniprot:	P54762
Entrez:	2047

Family

Belongs to:
protein kinase superfamily

Alternative Names

Cek6; EC 2.7.10; EC 2.7.10.1; EK6; Elk; EPH receptor B1; eph tyrosine kinase 2; EphB1; EPH-like kinase 6; ephrin type-B receptor 1; EPHT2FLJ37986; Hek6; Net; NETHek6; soluble EPHB1 variant 1; Tyrosine-protein kinase receptor EPH-2

Molecular Weight

Mass (kDA):
109.885 kDA

Genomic Context

Human
Location:	3q22.2
Sequence:	3; NC_000003.12 (134595264..135260467)

Tissue Specificity

Preferentially expressed in brain.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein. Early endosome membrane. Cell projection, dendrite.

Diseases

• Neoplasms
• Nervousness
• Tumor Angiogenesis
• Malignant Neoplasms
• Carcinoma
• Tissue Adhesions
• Pain
• Hyperalgesia
• Carcinogenesis
• Pathologic Neovascularization
• Neuralgia
• Hyperalgesias, Mechanical
• Nerve Damage

• Thermal Hyperalgesia
• Cell Transformation, Neoplastic
• Adenocarcinoma
• Tumor Progression
• Malignant Neoplasm Of Lung
• Colorectal Cancer
• Nerve Degeneration

Interacting Proteins

• GRB10
• GRB2
• GRB7

Pathways

• Angiogenesis
• Axon Guidance
• Cell Migration
• Cell Adhesion
• Cell Proliferation
• Regeneration
• Pathogenesis
• Localization
• System Development
• Vasculogenesis
• Reflex
• Cell Motility
• Cell-cell Recognition

• Integrin Activation
• Platelet Aggregation
• Sensitization
• Chemotaxis
• Endocytosis
• Methylation
• Secretion

PTMs

• Phosphorylation

• Methylation

• Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EPHB1

Boster Bio - Best Uses Of The EPHB1 Marker

This article will discuss Boster Bio's anti-EphB1/2 antibody, cell-based ELISA kit, and qRT-PCR. The information is relevant to any scientist. Read on to learn how the EPHB1 marker can benefit your research. It is applicable to all scientists worldwide. This article also outlines a few tips for performing qRT-PCR on samples.

Boster Bio's anti-EphB1/2 antibody

This Boster Bio's anti-EpbB1/2 antibody recognizes the EPHB1 marker. This antibody reacts with human, mouse, and rat tissues. The manufacturer provides technical support and product credits for scientists who are working on specific species or applications. The product is available in several colors, including brown, yellow, blue, and red. For more information, please read our product datasheet.

ephrinB1-Fc is expressed by keratocytes during bFGF-induced corneal vascularization. EphB1 colocalized with vascular endothelial cells. It was found that ephrinB1-Fc alone did not cause angiogenesis unless there was a pre-existing new vessel. Moreover, knockdown of ephrinB1 induced a synergistic effect on capillary tube formation in vitro and vivo.

MiR-129-5p, an inhibitor of EphB1, targets the EPhB1/EphB2 signaling pathway. The researchers used BCP mice model to identify EphB1-miR-129-5p inhibitors and miR-129-5p mimics. The results of the assay demonstrated a significant inhibition of EphB1-MiR-129-5p in Wt-miR-129-5p/EphB1 but not in Mut-miR-129-5p/EPhB1-miR-129-5p inhibitors.

EphB1/2 expression is found in the left cornu of the medullae spinalis. In the present study, EphB3-Fc decreased the frequency of epileptic seizures and reduced DCX-labeled neuronal progenitor cell proliferation. These results suggest that EphB3-Fc may function as a protective factor in epileptic animals.

The effect of EphB3-Fc treatment on reelin pathway expression was also observed. In the control group, no significant changes were observed. Meanwhile, p-Dab1 was detected using Western blot analysis. The positive control group contained cells that expressed EphB3-Fc and the EPHB1-Fc combination. The results of this study suggest that EphB3-Fc is a potent tool for the diagnosis of epilepsy.

Using this product is a valuable tool in immunodiagnostic research and for drug discovery. It is distributed under a Creative Commons Attribution License. It was also shown to improve the detection of the EPHB1 marker. This article is distributed under a Creative Commons Attribution License. Please contact us for further information and pricing. You can order the anti-EphB1/2 antibody today!

Boster Bio's cell-based ELISA kit

If you are interested in quantitative detection of the EPHB1 marker in human cells, you may be interested in using Boster Bio's Cell Based ELISA Kit for EPHB1+2+3+4. This kit is designed to capture the EPHB1+2+3+4 protein and detect it by HRP-conjugated secondary antibodies. The HRP enzyme is capable of catalyzing a colorimetric reaction.

qRT-PCR

There are several ways to use the EPHB1 marker in your experiments. In this article, you'll learn about some of the best uses for this marker. Boster Bio offers the EPHB1 marker as a product with a catalog number of A02811-2. It reacts with Human, Mouse, and Rat. If you're using this product in your experiments, you can also submit your results for special species and applications. These results will be published for other researchers to use for further research.

Boster Bio is an antibody manufacturer specializing in picogram sensitivity ELISA kits and IHC optimized polyclonal antibodies. Their antibody line includes over 12,000 antibodies with high affinity and sensitivity. Boster Bio antibodies are validated for use in immunohistochemistry, ELISA, and WB. In addition to their sensitivity, Boster Bio antibodies are validated against a panel of 250 tissues and untransfected cell lines.