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Ephrin type-A receptor 8 Antibodies
AND EPHA8 ELISA kits, Ephrin type-A receptor 8 Proteins
Many biological assays use antibodies to detect Ephrin type-A receptor 8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ephrin type-A receptor 8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ephrin type-A receptor 8 antibodies...
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EPHA8 Overview
Facts about Ephrin type-A receptor 8.
Ephrin type-A receptor 8 (EPHA8)
Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands living on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is known as forward signaling while the signaling pathway downstream of the ephrin ligand is known as reverse signaling.
The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. During development of the nervous system plays also a role in axon guidance.
Gene Information
| Human | |
|---|---|
| Gene Name: | EPHA8 |
| Uniprot: | P29322 |
| Entrez: | 2046 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
Eek; EK3; EPH- and ELK-related kinase; EPH- and ELK-related tyrosine kinase; EPH receptor A8; EphA8; EPH-like kinase 3; ephrin type-A receptor 8; Hek3; hydroxyaryl-protein kinase; KIAA1459; protein-tyrosine kinase; tyrosine-protein kinase receptor EEK; tyrosylprotein kinase
Molecular Weight
Mass (kDA):
111.003 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p36.12 |
| Sequence: | 1; NC_000001.11 (22563489..22603595) |
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Cell projection. Early endosome membrane. Undergoes clathrin-mediated endocytosis upon EFNA5-binding and is targeted to early endosomes.
Diseases
- Tissue Adhesions
- Malignant Neoplasms
- Carcinogenesis
- Neoplasms
- Nervousness
- Neuroblastoma
- Malignant Neoplasm Of Brain
- Malignant Tumor Of Colon
- Glioma
- Malignant Neoplasm Of Lung
- Carcinoma
- Tumor Angiogenesis
- Pituitary Diseases
Pathways
- Cell Migration
- Cell Adhesion
- Endocytosis
- Regeneration
- Cell-cell Adhesion
- Clathrin-mediated Endocytosis
- Monocyte Chemotaxis
- Odontogenesis
- Chemotaxis
- Tissue Regeneration
- Translation
PTMs
- Phosphorylation
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EPHA8
bosterbio.com/bosterbio-gene-info-cards/EPHA8
References
PMID: 1648701 by Chan J., et al. eek and erk, new members of the eph subclass of receptor protein- tyrosine kinases.
PMID: 10498895 by Choi S., et al. Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity.