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Ephrin type-A receptor 5 Antibodies
AND EPHA5 ELISA kits, Ephrin type-A receptor 5 Proteins
Many biological assays use antibodies to detect Ephrin type-A receptor 5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ephrin type-A receptor 5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ephrin type-A receptor 5 antibodies...
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EPHA5 Infographic by Boster Bio
All EPHA5 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
WB
$370
Cat # PB9583
100 μg/vial
Cat # PB9583
100 μg/vial
Human, Mouse, Rat
ELISA
$480
Cat # EKC1191
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1191
1 kit, containing one 96-well plate and all necessary reagents
EPHA5 Overview
Facts about Ephrin type-A receptor 5.
Ephrin type-A receptor 5 (EPHA5)
Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands living on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is known as forward signaling while the signaling pathway downstream of the ephrin ligand is known as reverse signaling.
One of GPI-anchored ephrin-A ligands, EFNA5 most likely constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino- hippocampal and hippocamposeptal pathways.
Gene Information
| Human | |
|---|---|
| Gene Name: | EPHA5 |
| Uniprot: | P54756 |
| Entrez: | 2044 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
Bsk; Cek7; EC 2.7.10; EC 2.7.10.1; Ehk1; EHK-1; EHK1Hek7; EK7; EPH homology kinase 1; Eph homology kinase-1; EPH receptor A5; EphA5; EPH-like kinase 7; ephrin type-A receptor 5; Hek7; receptor protein-tyrosine kinase HEK7; Rek7; TYRO4HEK7CEK7; tyrosine-protein kinase receptor EHK-1
Molecular Weight
Mass (kDA):
114.803 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q13.1-q13.2 |
| Sequence: | 4; NC_000004.12 (65319563..65670495, complement) |
Tissue Specificity
Almost exclusively expressed in the nervous system in cortical neurons, cerebellar Purkinje cells and pyramidal neurons within the cortex and hippocampus. Display an increasing gradient of expression from the forebrain to hindbrain and spinal cord.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite.
Diseases
- Nervousness
- Malignant Neoplasms
- Neoplasms
- Tissue Adhesions
- Malignant Neoplasm Of Breast
- Carcinoma
- Glioblastoma
- Glioma
- Neoplasm Metastasis
- Muscular Fasciculation
- Tumor Angiogenesis
- Liver Carcinoma
- Optic Nerve Injuries
Pathways
- Axon Guidance
- Regeneration
- Cell Migration
- Cell Adhesion
- Brain Development
- Segmentation
- Dna Methylation
- Localization
- Methylation
- Innervation
- System Development
- Demethylation
- Angiogenesis
PTMs
- Phosphorylation
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EPHA5
bosterbio.com/bosterbio-gene-info-cards/EPHA5
References
PMID: 9191074 by Miescher G.C., et al. Extensive splice variation and localization of the EHK-1 receptor tyrosine kinase in adult human brain and glial tumors.
PMID: 7898931 by Fox G.M., et al. cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases.