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Ephrin type-A receptor 2 Antibodies
AND EPHA2 ELISA kits, Ephrin type-A receptor 2 Proteins
Many biological assays use antibodies to detect Ephrin type-A receptor 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ephrin type-A receptor 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ephrin type-A receptor 2 antibodies...
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EPHA2 Infographic by Boster Bio
All EPHA2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A00578
100 μg/vial
Cat # A00578
100 μg/vial
Human EphA2 ELISA Kit PicoKine®
11 Q&As
Human
ELISA
$499
Cat # EK1797
96 wells/kit, with removable strips.
Cat # EK1797
96 wells/kit, with removable strips.
Human, Rat
ELISA
$480
Cat # EKC1190
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1190
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2252
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2252
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA, IF, WB
$380
Cat # A00578Y588-2
100ul
Cat # A00578Y588-2
100ul
EPHA2 Overview
Facts about Ephrin type-A receptor 2.
Ephrin type-A receptor 2 (EPHA2)
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands living on adjacent cells, resulting in contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is known as forward signaling while the signaling pathway downstream of the ephrin ligand is known as reverse signaling.
Activated from the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway.
Gene Information
| Human | |
|---|---|
| Gene Name: | EPHA2 |
| Uniprot: | P29317 |
| Entrez: | 1969 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
ARCC2; EC 2.7.10; EC 2.7.10.1; Eck; ECKepithelial cell receptor protein tyrosine kinase; EPH receptor A2; EphA2; ephrin type-A receptor 2; Epithelial cell kinase; Myk2; Sek2; soluble EPHA2 variant 1; Tyrosine-protein kinase receptor ECK
Molecular Weight
Mass (kDA):
108.266 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p36.13 |
| Sequence: | 1; NC_000001.11 (16124337..16156104, complement) |
Tissue Specificity
Expressed in brain and glioma tissue and glioma cell lines (at protein level). Expressed most highly in tissues that contain a high proportion of epithelial cells, e.g. skin, intestine, lung, and ovary.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single-pass type I membrane protein. Cell junction, focal adhesion. Present at regions of cell-cell contacts but also at the leading edge of migrating cells (PubMed:19573808, PubMed:20861311). Relocates from the plasma membrane to the cytoplasmic and perinuclear regions in cancer cells (PubMed:18794797).
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Neoplasm Metastasis
- Tissue Adhesions
- Tumor Angiogenesis
- Pathologic Neovascularization
- Cell Invasion
- Malignant Paraganglionic Neoplasm
- Mammary Neoplasms
- Malignant Neoplasm Of Breast
- Cell Transformation, Neoplastic
Interacting Proteins
- CTNNB1
- EFNA1
- EFNA5
- EPHA7
- HSP90AB1
- PTK2
- PTPN11
Pathways
- Angiogenesis
- Cell Migration
- Cell Adhesion
- Cell Proliferation
- Cell Growth
- Pathogenesis
- Localization
- Axon Guidance
- Oncogenesis
- Gene Silencing
- Cell Cycle
- Endocytosis
- Rna Interference
PTMs
- Phosphorylation
- Dephosphorylation
- Cleavage
- Methylation
Research Areas
- Cancer
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EPHA2
bosterbio.com/bosterbio-gene-info-cards/EPHA2
References
PMID: 2174105 by Lindberg R.A., et al. cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases.
PMID: 18593464 by Jin P., et al. Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.