ENPP6 Antibodies

AND ENPP6 ELISA kits, ENPP6 Proteins

Many biological assays use antibodies to detect ENPP6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ENPP6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ENPP6 antibodies...

We validate the specificity of these antibodies to ENPP6 by testing them on tissues known to express ENPP6 positively and negatively. Browse below to find the ENPP6 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ENPP6 Infographic by Boster Bio

All ENPP6 Products

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Specificity

Applications

Price

ENPP6 (NM_153343) Human Recombinant Protein

$813
Cat # PROTQ6UWR7
20 µg

ENPP6 (NM_153343) Human Over-expression Lysate

Human

$628
Cat # LS133121
100 µg

ENPP6 Overview

Facts about Glycerophosphocholine cholinephosphodiesterase ENPP6.

ENPP6 3D structure. Source: alphafold

Glycerophosphocholine cholinephosphodiesterase ENPP6 (ENPP6)

The preferred substrate might be lysosphingomyelin (By similarity). Hydrolyzes lysophosphatidylcholine (LPC) to form monoacylglycerol and phosphorylcholine but not lysophosphatidic acid, showing it has a lysophospholipase C activity.

Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. Also hydrolyzes glycerophosphorylcholine and sphingosylphosphorylcholine efficiently.

Gene Information

Human
Gene Name:	ENPP6
Uniprot:	Q6UWR7
Entrez:	133121

Family

Belongs to:

nucleotide pyrophosphatase/phosphodiesterase family

Alternative Names

B830047L21Rik; EC 3.1; ectonucleotide pyrophosphatase/phosphodiesterase 6; ectonucleotide pyrophosphatase/phosphodiesterase family member 6; E-NPP 6; ENPP6; ENPP-6; GPC-Cpde; MGC33971; NPP6; NPP-6

Molecular Weight

Mass (kDA):
50.241 kDA

Genomic Context


Human

Location:	4q35.1
Sequence:	4; NC_000004.12 (184088706..184217873, complement)

Tissue Specificity

Predominantly expressed in kidney and brain. In the kidney, expressed specifically in the proximal tubules and thin descending limbs of Henle (at protein level).

Subcellular Localizations

Cell membrane; Lipid-anchor, GPI-anchor. A small amount of the protein may be found in the extracellular milieu.

Diseases

Malignant Neoplasms
Obesity
Mammary Neoplasms
Iron Deficiency

Pathways

Brain Development

PTMs

Disulfide bond
Glycoprotein

GPI-anchor
Lipoprotein

Phosphoprotein

Research Areas

Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ENPP6

References

PMID: 15788404 by Sakagami H., et al. Biochemical and molecular characterization of a novel choline- specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase family.

PMID: 23161088 by Greiner-Tollersrud L., et al. Bovine brain myelin glycerophosphocholine choline phosphodiesterase is an alkaline lysosphingomyelinase of the eNPP-family, regulated by lysosomal sorting.