This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
ENPP2 Antibodies
AND ENPP2 ELISA kits, ENPP2 Proteins
Many biological assays use antibodies to detect ENPP2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ENPP2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ENPP2 antibodies...
Previous: CBLIF
Next: ENPP3
ENPP2 Infographic by Boster Bio
All ENPP2 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$750
Cat # EK1655
96 wells/kit, with removable strips.
Cat # EK1655
96 wells/kit, with removable strips.
ENPP2 Overview
Facts about Ectonucleotide pyrophosphatase/phosphodiesterase family member 2.
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (ENPP2)
Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids (PubMed:15769751, PubMed:26371182, PubMed:27754931). Also can act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility.
Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP (PubMed:15769751, PubMed:12176993). Involved in several motility-related processes such as angiogenesis and neurite outgrowth.
Gene Information
| Human | |
|---|---|
| Gene Name: | ENPP2 |
| Uniprot: | Q13822 |
| Entrez: | 5168 |
Family
| Belongs to: |
|---|
| nucleotide pyrophosphatase/phosphodiesterase family |
Alternative Names
ATX; ATXFLJ26803; ATX-X; Autotaxin; autotaxin-t; EC 3.1.4.39; ectonucleotide pyrophosphatase/phosphodiesterase 2; ectonucleotide pyrophosphatase/phosphodiesterase family member 2; E-NPP 2; ENPP2; ENPP-2; Extracellular lysophospholipase D; Lysophosphatidic Acid; LysoPLD; NPP2; PD-IALPHA; PDNP2; PDNP2NPP2; phosphodiesterase I/nucleotide pyrophosphatase 2; plasma lysophospholipase D
Molecular Weight
Mass (kDA):
98.994 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q24.12 |
| Sequence: | 8; NC_000008.11 (119557085..119673404, complement) |
Tissue Specificity
Detected in blood plasma (at protein level) (PubMed:12176993, PubMed:26371182). Predominantly expressed in brain, placenta, ovary, and small intestine. Expressed in a number of carcinomas such as hepatocellular and prostate carcinoma, neuroblastoma and non-small-cell lung cancer. Expressed in body fluids such as plasma, cerebral spinal fluid (CSF), saliva, follicular and amniotic fluids. Not detected in leukocytes. Isoform 1 is more highly expressed in peripheral tissues than in the central nervous system (CNS). Adipocytes only express isoform 1. Isoform 3 is more highly expressed in the brain than in peripheral tissues.
Subcellular Localizations
Secreted.
Diseases
- Malignant Neoplasms
- Neoplasms
- Inflammation
- Tissue Adhesions
- Neoplasm Metastasis
- Malignant Neoplasm Of Breast
- Tumor Angiogenesis
- Carcinoma
- Fibrosis
- Mammary Neoplasms
- Melanoma
- Hypoxia
- Tumor Progression
Pathways
- Cell Growth
- Cell Motility
- Cell Proliferation
- Angiogenesis
- Cell Adhesion
- Pathogenesis
- Cell Migration
- Lung Development
- Immune Response
- Oligodendrocyte Differentiation
- Transport
- Cell Activation
- Muscle Cell Differentiation
PTMs
- Phosphorylation
- Carboxylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ENPP2
bosterbio.com/bosterbio-gene-info-cards/ENPP2
References
PMID: 7982964 by Murata J., et al. cDNA cloning of the human tumor motility-stimulating protein, autotaxin, reveals a homology with phosphodiesterases.
PMID: 8586446 by Kawagoe H., et al. Molecular cloning and chromosomal assignment of the human brain-type phosphodiesterase I/nucleotide pyrophosphatase gene (PDNP2).