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, No Gclids
ENOX2 Antibodies
AND ENOX2 ELISA kits, ENOX2 Proteins
Many biological assays use antibodies to detect ENOX2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ENOX2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ENOX2 antibodies...
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ENOX2 Overview
Facts about Ecto-NOX disulfide-thiol exchanger 2.
Ecto-NOX disulfide-thiol exchanger 2 (ENOX2)
May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors in the cell surface.
Hydroquinone oxidase activity alternates with a protein disulfide- thiol interchange/oxidoreductase activity which might control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.
Gene Information
| Human | |
|---|---|
| Gene Name: | ENOX2 |
| Uniprot: | Q16206 |
| Entrez: | 10495 |
Family
| Belongs to: |
|---|
| ENOX family |
Alternative Names
COVA1; Cytosolic ovarian carcinoma antigen 1APK1 antigen; ecto-NOX disulfide-thiol exchanger 2; tNOXAPK1; Tumor-associated hydroquinone oxidase
Molecular Weight
Mass (kDA):
70.082 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xq26.1 |
| Sequence: | X; NC_000023.11 (130622330..130903317, complement) |
Tissue Specificity
Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Not found in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed into serum by cancer cells. Found on the cell borders of renal, kidney and ovarian carcinomas but not on the borders of surrounding non-cancerous stromal cells.
Subcellular Localizations
Cell membrane. Secreted, extracellular space. Extracellular and plasma membrane-associated.
Diseases
- Malignant Neoplasms
- Neoplasms
- Uterine Cervical Neoplasm
- Carcinoma
- Stomach Neoplasms
- Malignant Tumor Of Cervix
- Malignant Neoplasm Of Stomach
- Melanoma
- Colonic Neoplasms
- Malignant Tumor Of Colon
- Scleroderma
- Malignant Neoplasm Of Lung
Interacting Proteins
- CIB3
- ENOX1
- SNRPA
- TRAF5
Pathways
- Cell Proliferation
- Cell Growth
- Transport
- Electron Transport
- Rna Interference
- Nadh Oxidation
- Hyperphosphorylation
- Cell Migration
- Programmed Cell Death
- Induction Of Apoptosis
- Cell Development
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ENOX2
bosterbio.com/bosterbio-gene-info-cards/ENOX2
References
PMID: 11888291 by Chueh P.-J., et al. Molecular cloning and characterization of a tumor-associated, growth- related, and time-keeping hydroquinone (NADH) oxidase (tNOX) of the HeLa cell surface.
PMID: 11437345 by Yantiri F., et al. Isolation and characterization of a tumor-associated NADH oxidase (tNOX) from the HeLa cell surface.