EIF4B Antibodies

Eukaryotic translation initiation factor 4B (EIF4B)

Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A.

Binds close to the 5'- terminal cap of mRNA in existence of EIF-4F and ATP. Promotes the ATPase activity as well as the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.

Gene Information

Human
Gene Name:	EIF4B
Uniprot:	P23588
Entrez:	1975

Family

Belongs to:
No superfamily

Alternative Names

Eif4a2; eIF4B; EIF-4B; eukaryotic translation initiation factor 4B; PRO1843

Molecular Weight

Mass (kDA):
69.151 kDA

Genomic Context

Human
Location:	12q13.13
Sequence:	12; NC_000012.12 (53006456..53042215)

Diseases

• Foot-and-mouth Disease
• Malignant Neoplasms
• Neoplasms
• Hepatitis
• Hepatitis C
• Carcinoma
• Malignant Paraganglionic Neoplasm
• Patient Dependence On
• Tumor Angiogenesis
• Precancerous Conditions
• Adenocarcinoma
• Aids-associated Nephropathy

• Malignant Squamous Cell Neoplasm
• Cell Transformation, Neoplastic
• Picornaviridae Infections
• Peritoneal Carcinomatosis
• Stomach Neoplasms
• Neoplasm Metastasis

Interacting Proteins

• PLK1
• TINF2

Pathways

• Translation
• Translational Initiation
• Cell Growth
• Cell Proliferation
• Induction Of Apoptosis
• Cell Death
• Regulation Of Translation
• Rna Interference
• Transport
• Cell Cycle
• Angiogenesis
• Hibernation
• Programmed Cell Death

• Pseudohyphal Growth
• Stress Granule Assembly
• Spermatogenesis
• Cell Cycle Arrest
• Cytokinesis
• Glucose Homeostasis
• Seed Development

PTMs

• Phosphorylation
• Cleavage

• Dephosphorylation
• Acetylation

Research Areas

• Core ESC-Like Genes
• mTOR Pathway
• Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EIF4B

Boster Bio: Best Uses Of The EIF4B Marker

Steven Boster was the inventor of his first product in 1993. He is now famous for his work in converting technology in the lavatory. He was the creator of a variety of products of immunohistochemistry (IHC), including hundreds of thousands of primary antibodies. Boster was China's biggest catalog antibody manufacturer by the end nineties. Boster's business developed a unique ELISA platform called PicoKine. PicoKine makes use of trade secrets in order to offer a high-sensitivity ELISA kit.

eIF4B

eIF4B is a highly conserved protein which functions as a transcription factor in the nucleus. Depletion of it causes cell proliferation to cease , and eIF5A expression increases the size of tumors and the sensitivity to conventional antiproliferative medications. The loss of eIF5A increases the size of tumors and the sensitivity of anti-proliferative drugs. Targeting eIF5A alongside routine chemotherapy could increase the effectiveness of cancer treatment. EIF5A is also vital for maintaining cell viability in anaerobic acidosis.

It is a crucial gene involved in cell division. It is essential to understand its function in regulating expression of genes. It could play a significant role in the regulation of genes. However the eIF4B gene remains unexplored. The gene is a possibility in a variety of areas related to cancer research. More research is needed in order to determine the role of eIF4B in the proliferation of cancer cells.

Boster Biological Technology provides a an lentivirus-based eIF4B marker for RNA-based research. It was used in conjunction with a human breast cancer line. It was grown in DMEM media with 10 percent bovine fetal serum. Boster Biological Technology uses a proprietary lentivirus for lentivirus-based expression. The gene is packaged into an LentiX Tet-On Advancing INCUTIVE expression system.

Many cancer research studies employ the eIF3g gene as a key one. The eIF3g gene is believed to connect biological processes to translation. eIF3g interacts with hnRNPU and the HSZFP36 protein, which is an essential element in the translation process. It could also be vital for cell cycle regulation. The eIF3g gene is also involved in mitosis and segregation.

Sirt1 acts as an extracellular pH sensor and transcription factor. It prevents the cytoplasmic export Tsc2mRNA to the cytoplasm which hinders the elongation of translation. Similarly, eIF4B regulates gene expression in eukaryotic cell cells and hinders the development of new proteins. Its expression in anaerobic cell is an indication of acidosis in anaerobic cells or the aging process.

Boster has a range of eIF5A1 antibodies that have been tested and validated. The boster antibody is highly specific for this gene. Furthermore, it also offers high-affinity primary antibodies for use in ELISA, immunohistochemistry, and Western Blotting. The boster antibodies are utilized extensively in research and have many years of experience of reliability.

NDRG1

The EIF4B gene marker is a gene that's widely expressed in a majority of tissues. Depletion causes metabolism re-start and the proliferation of cells. It functions as a translatome reorganizer, inhibiting metabolism to protect the genome. It plays a crucial role in cell development, metabolism, growth and many other functions. But what are the most effective uses for this gene?

The function of the EIF4B gene remains not well understood. It is an important protein that regulates gene expression. However it isn't clear how it affects cancer growth. This gene is involved in many aspects of cell biology, ranging from the regulation of gene expression, to the regulation of cell division. It also functions as an indicator for eIF3g and other proteins.

TSC2

The eIF4B gene plays a vital role in maintaining cell health especially when it comes to conditions like aplasia. The loss of this gene results in increased proliferation and DNA damage. This gene functions as a translatome reformer . It suppresses metabolism to protect DNA from damage. However, this gene plays a crucial role in human development. Boster Bio The Best Uses For The EIF4B Marker

The expression of eIF4B in cancer cells is regulated by its ability to promote the expression of eIF5A mRNA that is independent of it. It also plays an important role in regulation of anaerobic acidsis, where eIF5A regulates synthesis and export of Tsc2 proteins. Contrary to this, eIF5B depletion is not related to any change in the mRNA levels of the target.

It has been proven that eIF3g can interact with HSZFP36 and b-actin. The results of this study show that eIF3g is present in both the cytoplasmic and nucleus. The protein is also linked with DNA and RNA. This makes it an effective marker for detecting DNA damage, RNA strands and the cellular splicing.

Junc

The EIF4B gene is an essential element of the cell cycle that regulates metabolism in cells. The depletion of eIF4A cause cells to suffer DNA damage, metabolism reinitiation, proliferation and replication. Additionally, eIF4A functions as a translatome remodeler and suppresses metabolism to safeguard the genome. In the context of the cellular anatomy, the gene is involved in maintaining the cell cycle.

The EIF4AIII protein has a different relationship to eIF4B. It is associated with EIF4B in the cytoplasm but not in the nucleus. It is possible that eIF4B regulates the activity of eIF4AI during NMD. It is in contact with Y14 and Magoh.