Ehmt1 Antibodies

AND Ehmt1 ELISA kits, Ehmt1 Proteins

Many biological assays use antibodies to detect Ehmt1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ehmt1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ehmt1 antibodies...

We validate the specificity of these antibodies to Ehmt1 by testing them on tissues known to express Ehmt1 positively and negatively. Browse below to find the Ehmt1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Ehmt1 Infographic by Boster Bio

All Ehmt1 Products

Product

Figures

Specificity

Applications

Price

Anti-EHMT1 Antibody

Human, Mouse, Rat

$405
Cat # A02433
100ul

Anti-EHMT1 Monoclonal Antibody

Human

ELISA, WB

$380
Cat # M02433
100ul

EHMT1/GLP (EHMT1) (NM_024757) Human Over-expression Lysate

Human

$960
Cat # LS079813
100 µg

Ehmt1 Overview

Facts about Histone-lysine N-methyltransferase EHMT1.

Histone-lysine N-methyltransferase EHMT1 (Ehmt1)

Histone methyltransferase that especially mono- and dimethylates'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones.

Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity isn't required for DNA methylation, suggesting that these 2 activities function independently.

Gene Information

Mouse
Gene Name:	Ehmt1
Uniprot:	Q5DW34
Entrez:	77683

Family

Belongs to:

class V-like SAM-binding methyltransferase superfamily

Alternative Names

DEL9q34; EC 2.1.1.-; EC 2.1.1.43; EHMT1; euchromatic histone-lysine N-methyltransferase 1H3-K9-HMTase 5; Eu-HMTase1; Eu-HMTase1DEL9q34; EUHMTASE1FP13812; FLJ12879; G9a-like protein 1; GLP; GLP1; H3 lysine-9 specific 5; KIAA1876euchromatic histone methyltransferase 1; KMT1D; KMT1DDKFZp667M072; Lysine N-methyltransferase 1D

Molecular Weight

Mass (kDA):
141.999 kDA

Genomic Context


Mouse

Location:	2\|2 A3
Sequence:	2;

Tissue Specificity

Ubiquitous.

Diseases

Muscle Hypotonia
Haploinsufficiency
Malignant Neoplasms
Neoplasms
Epilepsy
Congenital Heart Defects
Cytogenetic Abnormality
Autistic Disorder
Chromosome Breakage
Brachycephaly
Orbital Separation Excessive
Sleep Disorders

Schizophrenia
Severe Mental Retardation
Indifferent Mood
Rheumatoid Arthritis
Mental Disorders
Chromosomal Translocation

Pathways

Methylation
Cognition
Histone Methylation
Dna Methylation
Chromatin Remodeling
Brain Development
Gene Silencing
Dna Hypomethylation
Mitosis
Dendrite Development
Regulation Of Gene Expression
Autolysis
Double-strand Break Repair

Embryo Development
Dna Replication
Histone Lysine Methylation
Social Behavior
Rna Processing
Chromatin Modification
Pathogenesis

PTMs

Methylation

Phosphorylation

Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Ehmt1

References

PMID: 15774718 by Tachibana M., et al. Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9.

PMID: 18818694 by Tachibana M., et al. G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription.