Egl nine homolog 2 Antibodies

AND EGLN2 ELISA kits, Egl nine homolog 2 Proteins

Many biological assays use antibodies to detect Egl nine homolog 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Egl nine homolog 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Egl nine homolog 2 antibodies...

We validate the specificity of these antibodies to Egl nine homolog 2 by testing them on tissues known to express EGLN2 positively and negatively. Browse below to find the EGLN2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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EGLN2 Infographic by Boster Bio

All EGLN2 Products

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Product

Figures

Specificity

Applications

Price

Anti-PHD1/prolyl hydroxylase Rabbit Monoclonal Antibody

6 Q&As

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # M03015
100 μl

Anti-EGLN2 Mouse Monoclonal Antibody [Clone ID: OTI7H3]

Human, Mouse, Rat

IHC, WB

$523
Cat # M03015-1
100 µl

EGLN2 (NM_053046) Human Over-expression Lysate

Human

$628
Cat # LS112398
100 µg

EGLN2 Overview

Facts about Egl nine homolog 2.

EGLN2 3D structure. Source: alphafold

Egl nine homolog 2 (EGLN2)

Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A.

Has a preference for the CODD website for both HIF1A and HIF2A. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation into the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes.

Gene Information

Human
Gene Name:	EGLN2
Uniprot:	Q96KS0
Entrez:	112398

Family

Belongs to:

No superfamily

Alternative Names

DKFZp434E026; EC 1.14.11; EC 1.14.11.-; egl nine homolog 2 (C. elegans); egl nine homolog 2; EGLN2; EIT6; Estrogen-induced tag 6; FLJ95603; HIFPH1 EGL nine (C.elegans) homolog 2; HIFPH1; HIF-PH1; HIF-prolyl hydroxylase 1; HPH-1; HPH-3; Hypoxia-inducible factor prolyl hydroxylase 1; PHD1; Prolyl hydroxylase domain-containing protein 1

Molecular Weight

Mass (kDA):
43.65 kDA

Genomic Context


Human

Location:	19q13.2
Sequence:	19; NC_000019.10 (40799191..40808434)

Tissue Specificity

Expressed in adult and fetal heart, brain, liver, lung, skeletal muscle, and kidney. Also expressed in testis and placenta. Highest levels in adult brain, placenta, lung, kidney, and testis. Expressed in hormone responsive tissues, including normal and cancerous mammary, ovarian and prostate epithelium.