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- Table of Contents
Facts about Ephrin-B1.
Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (PubMed:8070404, PubMed:7973638). Can also bind EPHB2 and EPHB3 (PubMed:8070404).
Human | |
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Gene Name: | EFNB1 |
Uniprot: | P98172 |
Entrez: | 1947 |
Belongs to: |
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ephrin family |
Cek5-L; EFL3; EFL-3; EFNB1; ELK ligand; ELK-L; EphrinB1; Ephrin-B1; LERK-2; STRA-1
Mass (kDA):
38.007 kDA
Human | |
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Location: | Xq13.1 |
Sequence: | X; NC_000023.11 (68829021..68842160) |
Widely expressed (PubMed:8070404, PubMed:7973638). Detected in both neuronal and non-neuronal tissues (PubMed:8070404, PubMed:7973638). Seems to have particularly strong expression in retina, sciatic nerve, heart and spinal cord (PubMed:7973638).
Cell membrane; Single-pass type I membrane protein. Membrane raft. May recruit GRIP1 and GRIP2 to membrane raft domains.; [Ephrin-B1 C-terminal fragment]: Cell membrane; Single-pass type I membrane protein.; [Ephrin-B1 intracellular domain]: Nucleus. Colocalizes with ZHX2 in the nucleus.
PMID: 8070404 by Beckmann M.P., et al. Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors.
PMID: 7973638 by Davis S., et al. Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity.