Transcription factor COE2 Antibodies

AND Ebf2 ELISA kits, Transcription factor COE2 Proteins

Many biological assays use antibodies to detect Transcription factor COE2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Transcription factor COE2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Transcription factor COE2 antibodies...

We validate the specificity of these antibodies to Transcription factor COE2 by testing them on tissues known to express Ebf2 positively and negatively. Browse below to find the Ebf2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Ebf2 Infographic by Boster Bio

All Ebf2 Products

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EBF2 (NM_022659) Human Recombinant Protein

$813
Cat # PROTQ9HAK2
20 µg

EBF2 (NM_022659) Human Over-expression Lysate

Human

$960
Cat # LS064641
100 µg

Ebf2 Overview

Facts about Transcription factor COE2.

Transcription factor COE2 (Ebf2)

Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt- responsive LEF1/CTNNB1 pathway.

Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. .

Gene Information

Mouse
Gene Name:	Ebf2
Uniprot:	O08792
Entrez:	13592

Family

Belongs to:

COE family

Alternative Names

COE2; EBF2; EBF-2; Mmot1

Molecular Weight

Mass (kDA):
62.606 kDA

Genomic Context


Mouse

Location:	14\|14 D1
Sequence:	14;

Tissue Specificity

In adult expressed in olfactory epithelium and at a much lower level in Purkinje cells of the cerebellum. In embryo expressed in epithalamus, in cells near the ventricular zone of mesencephalon and on the ventral surface of rhombencephalon, in the developing vomeronasal organ, at a lower level in developing spinal cord. Not expressed in developing retina, inner ear, dorsal root ganglia, trigeminal ganglia and glossopharyngeal ganglia.

Diseases

Nervousness
Lymphohistiocytosis, Hemophagocytic
Peripheral Neuropathy
Malignant Neoplasms
Neoplasms
Hypogonadotropic Hypogonadism
Hypogonadism
Neoplasm Metastasis
Bone Neoplasms
Narcolepsy
Myeloid Leukemia, Chronic

Eye Abnormalities
Motor Neuron Disease
Osteosarcoma
Dysplasia
Hemorrhage
Myeloid Leukemia

Pathways

Neurogenesis
Cell Death
Proteolysis
Cell Differentiation
Nerve Development
Lateral Inhibition
Neuron Migration
Cell Adhesion
Osteoclast Differentiation
Muscle Cell Differentiation
Hypersensitivity
Vasculogenesis
Limb Development

Myelination
Schwann Cell Differentiation
Chemotaxis
System Development
Cell Cycle
Gravitropism
Bone Development

PTMs

Ubiquitination

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Ebf2

References

PMID: 9211912 by Malgaretti N., et al. Mmot1, a new helix-loop-helix transcription factor gene displaying a sharp expression boundary in the embryonic mouse brain.

PMID: 9151732 by Wang S.S., et al. The characterization of the Olf-1/EBF-like HLH transcription factor family: implications in olfactory gene regulation and neuronal development.