Transcription factor E4F1 Antibodies

AND E4F1 ELISA kits, Transcription factor E4F1 Proteins

Many biological assays use antibodies to detect Transcription factor E4F1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Transcription factor E4F1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Transcription factor E4F1 antibodies...

We validate the specificity of these antibodies to Transcription factor E4F1 by testing them on tissues known to express E4F1 positively and negatively. Browse below to find the E4F1 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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E4F1 Infographic by Boster Bio

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E4F1 Overview

Facts about Transcription factor E4F1.

E4F1 3D structure. Source: alphafold

Transcription factor E4F1 (E4F1)

May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53.

Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription.

Gene Information

Human
Gene Name:	E4F1
Uniprot:	Q66K89
Entrez:	1877

Family

Belongs to:

No superfamily

Alternative Names

E4F transcription factor 1p50E4F; E4FMGC99614; EC 6.3.2.-; p120E4F; Putative E3 ubiquitin-protein ligase E4F1; Transcription factor E4F; transcription factor E4F1

Molecular Weight

Mass (kDA):
83.496 kDA

Genomic Context


Human

Location:	16p13.3
Sequence:	16; NC_000016.10 (2223488..2235742)

Tissue Specificity

Ubiquitously expressed.

Subcellular Localizations

Nucleus, nucleoplasm. Cytoplasm. A small fraction is detected in the cytoplasm. Excluded from the nucleolus where it is targeted upon CDKN2A overexpression. Localizes to the mitotic spindle during embryogenesis.

Diseases

Neoplasms
Cell Transformation, Neoplastic
Growth Arrest
Sarcoma
Leukemia, Myelocytic, Acute
Myeloid Leukemia
Mammary Neoplasms
Histiocytic Sarcoma
Leukemia
Hyperplasia
Cholangiocarcinoma
Neurodegenerative Disorders
Ataxia

Dysplasia
Malignant Neoplasms
Exhaustion
Lymphoma
Neuroblastoma
Congenital Absence
Congenital Abnormality

Interacting Proteins

ANP32A
HDAC1

Pathways

Cell Cycle
Cell Death
Cell Proliferation
Autophagic Cell Death
Osteoblast Differentiation
Mitosis
Stem Cell Maintenance
Proteolysis
M Phase
Keratinocyte Differentiation

Cell Cycle Arrest
Pronephros Formation
Cell Growth
Regulation Of Mrna Stability
Rna Interference

PTMs

Phosphorylation

Acetylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/E4F1

References

PMID: 9121437 by Fernandes E.R., et al. The adenovirus E1A-regulated transcription factor E4F is generated from the human homolog of nuclear factor phiAP3.

PMID: 9530632 by Rooney R.J., et al. Chromosomal location and tissue expression of the gene encoding the adenovirus E1A-regulated transcription factor E4F in humans and mice.