Transcription factor E2F7 Antibodies

AND E2f7 ELISA kits, Transcription factor E2F7 Proteins

Many biological assays use antibodies to detect Transcription factor E2F7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Transcription factor E2F7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Transcription factor E2F7 antibodies...

We validate the specificity of these antibodies to Transcription factor E2F7 by testing them on tissues known to express E2f7 positively and negatively. Browse below to find the E2f7 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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E2f7 Infographic by Boster Bio

All E2f7 Products

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Product

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Specificity

Applications

Price

Anti-Transcription factor E2F7 E2F7 Antibody

Human

ELISA, WB

$380
Cat # A04195
100ul

E2F7 (NM_203394) Human Over-expression Lysate

Human

$960
Cat # LS144455
100 µg

E2f7 Overview

Facts about Transcription factor E2F7.

Transcription factor E2F7 (E2f7)

Atypical E2F transcription factor that participates in a variety of processes such as angiogenesis, polyploidization of cells and DNA damage response. Mainly functions as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'- TTTC[CG]CGC-3'.

Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a crucial role in polyploidization of cells in placenta and liver by regulating the endocycle, likely by repressing genes promoting cytokinesis and antagonizing activity of ancient E2F proteins (E2F1, E2F2 and/or E2F3).

Gene Information

Mouse
Gene Name:	E2f7
Uniprot:	Q6S7F2
Entrez:	52679

Family

Belongs to:

E2F/DP family

Alternative Names

E2F transcription factor 7; E2F-7; FLJ12981; transcription factor E2F7

Molecular Weight

Mass (kDA):
99.535 kDA

Genomic Context


Mouse

Location:	10 D1\|10 57.74 cM
Sequence:	10;

Tissue Specificity

Widely expressed with highest levels in skin and thymus and very low levels in brain, muscle and stomach. Expressed in trophoblast giant cells throughout placenta development (at protein level).

Diseases

Neoplasms
Malignant Neoplasms
Carcinoma
Retinoblastoma
Hyperplasia
Cell Transformation, Neoplastic
Squamous Cell Carcinoma Of Skin
Drug-induced Liver Injury
Keratoconjunctivitis Sicca
Carcinogenesis
Injury To Liver
Tumor Angiogenesis

Malignant Neoplasm Of Ovary
Ovarian Neoplasm
Liver Regeneration Disorder
Hepatotoxicity
Rhabdomyosarcoma, Embryonal
Malignant Squamous Cell Neoplasm
Alveolar Rhabdomyosarcoma

Pathways

Cell Cycle
Cell Proliferation
Dna Replication
Mitosis
Cell Cycle Arrest
Dna Repair
Cell Division
Mitotic Cell Cycle
Cell Growth
Cell Cycle Checkpoint
Cellular Senescence
Regulation Of Gene Expression
Hepatocyte Proliferation

Liver Regeneration
Oncogene-induced Senescence
Regulation Of Cell Cycle
Senescence
Regeneration
Cell Death
S Phase

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/E2f7

References

PMID: 12893818 by de Bruin A., et al. Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation.

PMID: 18194653 by Li J., et al. Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development.