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Transcription factor E2F4 Antibodies
AND E2F4 ELISA kits, Transcription factor E2F4 Proteins
Many biological assays use antibodies to detect Transcription factor E2F4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Transcription factor E2F4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Transcription factor E2F4 antibodies...
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E2F4 Infographic by Boster Bio
All E2F4 Products
Product
Figures
Specificity
Applications
Price
Human, Rat
WB
$370
Cat # PA2156
100 μg/vial
Cat # PA2156
100 μg/vial
E2F4 Overview
Facts about Transcription factor E2F4.
Transcription factor E2F4 (E2F4)
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase.
E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1.
Gene Information
| Human | |
|---|---|
| Gene Name: | E2F4 |
| Uniprot: | Q16254 |
| Entrez: | 1874 |
Family
| Belongs to: |
|---|
| E2F/DP family |
Alternative Names
E2F transcription factor 4, p107/p130-binding; E2F4; E2F-4; E2F-4p107/p130-binding protein; transcription factor E2F4
Molecular Weight
Mass (kDA):
43.96 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16q22.1 |
| Sequence: | 16; NC_000016.10 (67192155..67198918) |
Tissue Specificity
Found in all tissue examined including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Subcellular Localizations
Nucleus.
Diseases
- Neoplasms
- Retinoblastoma
- Malignant Neoplasms
- Carcinoma
- Cell Transformation, Neoplastic
- Growth Arrest
- Carcinogenesis
- Mammary Neoplasms
- Hyperplasia
- Malignant Neoplasm Of Breast
- Microsatellite Instability
- Malignant Paraganglionic Neoplasm
- Colorectal Cancer
Interacting Proteins
- LIN9
- RBL2
- TFDP1
Pathways
- Cell Cycle
- Cell Proliferation
- S Phase
- Cell Growth
- Cell Cycle Arrest
- Localization
- Cell Death
- Dna Repair
- G1 Phase
- Cell Differentiation
- Mitosis
- Dna Replication
- Mismatch Repair
PTMs
- Phosphorylation
- Dephosphorylation
- Acetylation
- Methylation
- Deacetylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/E2F4
bosterbio.com/bosterbio-gene-info-cards/E2F4
References
PMID: 7958924 by Ginsberg D., et al. E2F-4, a new member of the E2F transcription factor family, interacts with p107.
PMID: 7958925 by Beijersbergen R.L., et al. E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo.